Clinical outcome in children with culture-negative acute otitis media

The Pediatric Infectious Disease Journal
Eugene LeibovitzRon Dagan

Abstract

Culture-negative AOM is often milder and associated with lower local/systemic inflammatory responses than culture-positive AOM. To compare the clinical outcome of culture-negative AOM with that of culture-positive AOM children. Children aged 3 to 35 months with AOM were enrolled in 11 double-tympanocentesis antibiotic efficacy studies documenting both bacteriologic (days 4-6 of treatment) and clinical outcome (days 11-14, end of treatment). Univariate analysis (age, gender, ethnicity, previous AOM history, and antibiotic treatment) between culture-negative and culture-positive AOM patients was performed by Student t test, ANOVA, or chi2 test. Those found to be significant were further submitted to multivariable regression analysis. A total of 1088 patients (mean age, 11.95 +/- 5.96 months, 209 culture-negative and 879 culture-positive AOM) were enrolled. No differences were recorded between culture-negative AOM and culture-positive AOM patients in age, gender, ethnicity and number of previous episodes. Seventy-four percent (650/879) culture-positive AOM patients achieved bacteriologic eradication within 3 to 5 days. Successful outcome (cured + improved) was recorded in 90% (189/209) culture-negative AOM patients versus 86% (758...Continue Reading

References

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Feb 19, 2008·The Pediatric Infectious Disease Journal·Ron DaganEugene Leibovitz

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Citations

Aug 17, 2011·The Pediatric Infectious Disease Journal·Nader ShaikhRichard H Schwartz
Apr 16, 2015·Acta Oto-laryngologica·Mirjana KostićVladimir Bedeković
Mar 20, 2020·Ear, Nose, & Throat Journal·Joel W JonesDouglas A Chen
Mar 9, 2021·Brazilian Journal of Otorhinolaryngology·Otavio Bejzman Piltcher, José Faibes Lubianca Neto
Aug 21, 2021·International Journal of Pediatric Otorhinolaryngology·Tal MaromSharon Ovnat Tamir
Aug 10, 2017·Pediatrics·Paula A TähtinenAino Ruohola

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