Clinical outcome in patients with bipolar I disorder, obsessive compulsive disorder or both

Human Psychopharmacology
Franca CentorrinoRoss J Baldessarini

Abstract

Bipolar disorder (BPD) is often comorbid with obsessive-compulsive (OCD) and other anxiety disorders, but the impact of such comorbidity on long-term outcome has not been evaluated systematically. Extensive follow-up assessments were carried out at 4.3 years after index hospitalizations in a mixed BPD-OCD group (N=20) compared to matched groups with BPD (N=22) or OCD (N=20) alone. At follow-up, ratings of functional status were similar across groups. Rehospitalizations were similar among BPD-OCD and BPD subjects, but 2.9-times more frequent among comorbid than OCD patients. OCD symptoms averaged 150% more severe in OCD than comorbid subjects, and were not measured in BPD subjects. Despite potential sampling bias with previously hospitalized subjects, the findings suggest that comorbid BPD-OCD patients may be clinically more similar to BPD than OCD patients, and that BPD-OCD comorbidity may not negatively impact the long-term clinical outcome.

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Citations

May 1, 2012·Journal of Neural Transmission·Klaus W LangeOliver Tucha
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology·Oi Shan Tang, Pak Chung Ho
Mar 3, 2015·Expert Opinion on Investigational Drugs·Giulio PerugiNunzio Bucci
Mar 7, 2009·Child and Adolescent Psychiatric Clinics of North America·Gagan Joshi, Timothy Wilens

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