Clinical outcome in pediatric refractory gastrointestinal Henoch-Schönlein purpura treated with mycophenolate mofetil.

European Journal of Pediatrics
Haiyan WangWeiping Tan

Abstract

The aim of the present study was to investigate the clinical outcome of mycophenolate mofetil in pediatric refractory gastrointestinal (GI) Henoch-Schönlein purpura (HSP). Most of the HSP patients with GI symptoms may benefit from early introduction of glucocorticoid; however, a number of patients still do not achieve remission following the administration of steroids. Therefore, the present study was to investigate the clinical features and the clinical outcome of mycophenolate mofetil in refractory GI HSP. A total of 110 HSP patients with a median onset age of 6.3 years were included. Sixty-one (55.5%) exhibited GI involvement, and 18 (18/61, 29.5%) presented with refractory GI involvement, with a median onset age of 6.3 years. Intractable abdominal pain, GI hemorrhage, intussusception, and chronic ulcers were common presentations of GI involvement. Of those refractory ones, Arthralgia was observed in 9 cases and renal involvement was observed in 13 cases. Glucocorticoids were administered in all 18 patients, but remission was not achieved. However, complete remission of abdominal pain was achieved in all patients within a median time of 3 days (1-14 days) after mycophenolate mofetil therapy. The infection rate of Epstein-Bar...Continue Reading

References

Aug 1, 2006·Journal of Pediatric Gastroenterology and Nutrition·Scott MartinJeremy J Gitomer
Aug 9, 2007·JAMA : the Journal of the American Medical Association·Xavier BoschEduard Mirapeix
Sep 14, 2007·Scandinavian Journal of Urology and Nephrology·Fatih DedeKursad Onec
Nov 20, 2009·Scandinavian Journal of Urology and Nephrology·R F AndersenS Rittig
Jul 16, 2010·International Journal of Rheumatology·A A NikibakhshL Gholizadeh
Jul 29, 2010·Renal Failure·Catharina VonendSamuel S Weinstein
Jan 21, 2011·Digestive Diseases and Sciences·Sunil SamuelWilliam J Sandborn
Nov 15, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yue DuYubin Wu
May 16, 2013·World Journal of Gastroenterology : WJG·Hong-Liang WangKai-Jiang Yu
Apr 1, 2015·World Journal of Radiology·Parameswaran Prathiba Rajalakshmi, Kalyanasundaram Srinivasan
Jun 27, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Ünal UlucaDuran Karabel

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