Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Vito Di MarcoItalian Association for the Study of the Liver (AISF) Lamivudine Study Group, Italy

Abstract

The effect of lamivudine treatment on the outcome of patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis is unclear. In a retrospective multicenter study, we have analyzed the virological events observed during lamivudine therapy in patients with HBeAg-negative chronic hepatitis and evaluated the correlation between virological response and clinical outcomes. Among 656 patients (mean age 49.1 years) included in the database, 54% had chronic hepatitis, 30% had Child-Turcotte-Pugh (CTP) A cirrhosis, and 16% had CTP B/C cirrhosis. On therapy (median 22 months, range 1-66), a virological response was obtained in 616 patients (93.9%). The rate of maintained virological response was 39% after 4 years. During follow-up, 47 (7.2%) patients underwent liver transplantation, liver disease worsened in 31 (4.7%), hepatocellular carcinoma (HCC) developed in 31 (4.7%), and 24 patients (3.6%) died of liver-related causes. Patients who had cirrhosis and who maintained virological response were less likely than those with viral breakthrough to develop HCC (P <.001) and disease worsening (P <.001). Survival was better in CTP A patients with cirrhosis and maintained virological response (P =.01 by rank test). Multivariate analys...Continue Reading

References

Dec 16, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P LamperticoM Colombo
Feb 14, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MelegariJ R Wands
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M I AllenL D Condreay
Oct 9, 1998·Journal of Hepatology·P HonkoopS W Schalm
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V Di MarcoA Craxì
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y F LiawC M Chu
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J L DienstagN Brown
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P VilleneuveE J Heathcote
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J HadziyannisC Papaioannou
Nov 14, 2000·Journal of Medical Virology·A L Ballard, E H Boxall
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R P PerrilloUNKNOWN Lamivudine North American Transplant Group
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L J StuyverR F Schinazi
May 29, 2001·Gastroenterology·A S LokJ H Hoofnagle
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S LokUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
May 23, 2002·Gastroenterology·Jean-Michel Pawlotsky
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George V PapatheodoridisStephanos J Hadziyannis
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hie-Won L HannUNKNOWN United States Lamivudine Compassionate Use Study Group
Feb 28, 2003·The New England Journal of Medicine·Stephanos J HadziyannisUNKNOWN Adefovir Dipivoxil 438 Study Group
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pietro LamperticoMassimo Colombo

❮ Previous
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Citations

Nov 28, 2008·Rheumatology International·Umut KalyoncuYusuf Bayraktar
Aug 12, 2009·Hepatology International·Yun-Fan LiawUNKNOWN Chronic Hepatitis B Guideline Working Party of the Asian-Pacific Association for the Study of the Liver
Sep 9, 2005·Current Opinion in Infectious Diseases·Alex Yui Hui, Joseph Jao-Yiu Sung
May 16, 2006·Digestive Diseases·Daniel Forton, Peter Karayiannis
Jun 17, 2010·Blood·Vito Di MarcoUNKNOWN Italian Association for the Study of the Liver
Sep 11, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Qing-Wei DuRong-Quan Fu
Sep 22, 2011·ClinicoEconomics and Outcomes Research : CEOR·Giorgio L ColomboSergio Di Matteo
Dec 6, 2008·World Journal of Gastroenterology : WJG·George V PapatheodoridisAthanasios J Archimandritis
Dec 8, 2011·World Journal of Gastroenterology : WJG·Xiao-Hong FanXiao-Yuan Xu
Jan 1, 2014·World Journal of Gastroenterology : WJG·Zhong-Ming Tan, Bei-Cheng Sun
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Alfredo Marzano
Sep 25, 2008·Future Microbiology·George V Papatheodoridis, Melanie Deutsch
Feb 6, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Faisal AbaalkhailWaleed Al-Hamoudi
Dec 2, 2011·Current Hepatitis Reports·Yuk-Fai LamChing-Lung Lai
May 6, 2010·Wiener klinische Wochenschrift·Markus Peck-RadosavljevicWolfgang Vogel
Aug 24, 2011·Digestive Diseases and Sciences·Ke-Qin HuDiane Goodwin
Jun 13, 2008·Der Internist·J WiegandH L Tillmann
Nov 19, 2009·Der Internist·C P Strassburg, M Cornberg
Jul 17, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeFabien Zoulim
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Yun-Fan LiawUNKNOWN Asian-Pacific consensus update working party on chronic hepatitis B
Jun 18, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George V PapatheodoridisStephanos J Hadziyannis
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Pietro Lampertico, Massimo Colombo
May 3, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mari Inada, Osamu Yokosuka
Mar 25, 2006·Alimentary Pharmacology & Therapeutics·S ManolakopoulosD Tzourmakliotis
Feb 14, 2006·Internal Medicine Journal·G C Farrell, N C Teoh
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pietro LamperticoMassimo Colombo
Jul 25, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byung Chul YooHyo-Suk Lee
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Pietro LamperticoMassimo Colombo
Jan 11, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Yun-Fan Liaw
Mar 31, 2016·Hepatology International·Akinobu TawadaOsamu Yokosuka
Jan 3, 2006·Transplantation Proceedings·C CamciA Sebastian
Dec 17, 2005·Journal of Hepatology·Antonio CraxìCalogero Cammà
May 16, 2007·Expert Opinion on Investigational Drugs·Stephanos J Hadziyannis
Aug 22, 2006·Expert Opinion on Biological Therapy·Stephanos J Hadziyannis
Jan 6, 2011·Expert Opinion on Biological Therapy·Mauro Viganò, Pietro Lampertico
Dec 31, 2014·Expert Opinion on Drug Safety·Ezequiel Ridruejo

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