Clinical outcome of older patients with acute coronary syndrome over the last three decades

Age and Ageing
Eng Wei TangGerard T Wilkins

Abstract

To Evaluate the clinical outcome of patients with acute coronary syndrome (ACS) in the Coronary Care Unit (CCU) over three decades in Dunedin, New Zealand. Registry study. all consecutive patients (n = 3,013) with ACS admitted to the CCU from 1979 to 1981 (n = 966) and from 1989 to 1991 (n = 1470) were included prospectively. Data on ACS patients managed in the CCU in 2001-2002 (n = 577) were obtained via medical chart review. There was a rising proportion of older (> or = 75 years of age) patients with ACS (3.8% in 1979-1981, 15.2% in 1989-1991 and 25.6% in 2001-2002, P < 0.0005). However, we observed a progressive reduction of in-hospital mortality for ACS (10.7, 7.3 and 5.0%, P < 0.005) and for ST-elevation myocardial infarction (STEMI) (18.4, 16.1 and 6.6%, P < 0.005). The progressive fall in mortality rate was also observed amongst older patients, both for ACS (27, 19.2 and 11.5%, P = 0.011) and for STEMI (34.8, 30.9 and 15.4%, P < 0.005). Of concern, only 10% of patients presented within 1 h of symptom onset and 50% within 5 h, and this has not changed over three decades. The variables associated with < 5 h from symptom onset to presentation were men [odds ratio (OR) 1.25, 95% confidence interval (CI) 1.10-1.42, P = 0.001...Continue Reading

References

Sep 1, 1991·Journal of the American College of Cardiology·J J de VreedeH J Wellens
Feb 1, 1997·Journal of the American College of Cardiology·R A StewartN J Restieaux
Feb 19, 1997·JAMA : the Journal of the American Medical Association·M G HuninkM C Weinstein
Sep 24, 1998·The New England Journal of Medicine·D Levy, T J Thom
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Apr 30, 2003·Archives of Internal Medicine·Ulf StenestrandUNKNOWN Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA)
Nov 5, 2003·Circulation·Jean C McSweeneyBonnie J Garvin

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