Clinical outcome of stereotactic body radiotherapy for primary and oligometastatic lung tumors: a single institutional study with almost uniform dose with different five treatment schedules

Radiation Oncology
Masahiko AokiYoshihiro Takai

Abstract

To evaluate clinical outcomes of stereotactic body radiotherapy (SBRT) for localized primary and oligometastatic lung tumors by assessing efficacy and safety of 5 regimens of varying fraction size and number. One-hundred patients with primary lung cancer (n = 69) or oligometastatic lung tumors (n = 31), who underwent SBRT between May 2003 and August 2010, were included. The median age was 75 years (range, 45-88). Of them, 98 were judged to have medically inoperable disease, predominantly due to chronic illness or advanced age. SBRT was performed using 3 coplanar and 3 non-coplanar fixed beams with a standard linear accelerator. Fraction sizes were escalated by 1 Gy, and number of fractions given was decreased by 1 for every 20 included patients. Total target doses were between 50 and 56 Gy, administered as 5-9 fractions. The prescribed dose was defined at the isocenter, and median overall treatment duration was 10 days (range, 5-22). The median follow-up was 51.1 months for survivors. The 3-year local recurrence rates for primary lung cancer and oligometastasis was 6 % and 3 %, respectively. The 3-year local recurrence rates for tumor sizes ≤3 cm and >3 cm were 3 % and 14 %, respectively (p = 0.124). Additionally, other factors...Continue Reading

References

Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·R F Kallman, M J Dorie
Feb 15, 1993·International Journal of Radiation Oncology, Biology, Physics·D A LarsonJ S Loeffler
Oct 13, 2001·International Journal of Radiation Oncology, Biology, Physics·M UematsuS Kusano
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Rikiya OnimaruHirotoshi Dosaka-Akita
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Holger HofJürgen Debus J
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Timothy M Pawlik, Khandan Keyomarsi
Mar 22, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Frank B ZimmermannBranislav Jeremic
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Yasushi NagataMasahiro Hiraoka
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Nathalie CrokartBernard Gallez
Sep 21, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Natsuo TomitaHiromitsu Iwata
Nov 21, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Masashi KotoShogo Yamada
Aug 30, 2008·Seminars in Radiation Oncology·John P KirkpatrickLawrence B Marks
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Yasushi NagataHiroki Shirato
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Yukinori MatsuoMasahiro Hiraoka
May 19, 2010·The Journal of Thoracic and Cardiovascular Surgery·Neal E DunlapDavid R Jones
Jul 20, 2010·International Journal of Radiation Oncology, Biology, Physics·Hiroshi OnishiTsutomu Araki
Sep 3, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Suneil JainPatrick Cheung
Aug 12, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Osamu SuzukiJoachim Widder
Sep 20, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthias GuckenbergerFlorian Sterzing

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Citations

Mar 24, 2016·Journal of Radiation Research·Yuta ShibamotoHiromitsu Iwata
May 23, 2016·The Journal of Thoracic and Cardiovascular Surgery·Gaetano Rocco
Dec 23, 2016·The British Journal of Radiology·Neil B DesaiRobert D Timmerman
Jan 4, 2017·Interactive Cardiovascular and Thoracic Surgery·Ryu KanzakiMeinoshin Okumura

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