Clinical outcome with adjuvant treatment of endometrial carcinoma using intensity-modulated radiation therapy

Gynecologic Oncology
Sushil BeriwalJoseph Kelley

Abstract

To assess local control and chronic toxicity with IMRT for adjuvant treatment of endometrial carcinoma. Forty-seven patients with endometrial cancer were treated with adjuvant IMRT and HDR brachytherapy (HDRB). The external beam dose was between 45 and 50.4 Gy, and all patients received 10 Gy in 2 fractions of HDRB to the vaginal cuff. Eight of these patients were treated with extended field to include the paraaortic region. IMRT dosimetry showed excellent coverage of the planning target volume (PTV) with mean PTV 95, PTV 110 and PTV 120 of 97.8%, 8.2% and 0.9% respectively. At a median follow-up of 20 months, four patients have recurred at extra pelvic sites. No patient had pelvic recurrence. The treatment was well tolerated with late toxicities as follows: small bowel grade 1: 25%, rectal grade 1: 2% and bladder grade 1: 13%. One patient had grade 3 small bowel toxicity. The 3-year actuarial rate of grade 2 or greater toxicity, disease-free survival and overall survival rate were 3.3%, 84% and 90%, respectively. The preliminary analysis of IMRT for adjuvant treatment of endometrial carcinoma shows excellent local control and low toxicity. However, longer follow-up and more patients are needed to ascertain whether the benefits...Continue Reading

References

Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·J C RoeskeA J Mundt
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C. MacLeodJ. Carter
Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Arno J MundtJohn C Roeske
Nov 3, 2005·Nature Clinical Practice. Oncology·Avraham Eisbruch

❮ Previous
Next ❯

Citations

Feb 16, 2016·Gynecologic Oncology·Anupama ChunduryJulie K Schwarz
Nov 24, 2012·Gynecologic Oncology·Karin K ShihKaled M Alektiar
Mar 2, 2012·International Journal of Radiation Oncology, Biology, Physics·Katrien VandecasteeleGert De Meerleer
May 10, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R MazeronC Haie-Meder
Nov 3, 2009·The Lancet Oncology·Siriwan TangjitgamolUNKNOWN Asian Oncology Summit
Aug 29, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·R YangJ Wang
Nov 10, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Abel CordobaEric Lartigau
Jan 21, 2015·Critical Reviews in Oncology/hematology·Rockne HymelCharles B Simone
Jun 7, 2011·International Journal of Radiation Oncology, Biology, Physics·Eleanor E R HarrisKenneth Forster
Feb 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Sushil BeriwalRobert P Edwards
Jan 1, 2013·International Journal of Radiation Oncology, Biology, Physics·Sushil BeriwalThomas C Krivak
Mar 19, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Isabelle BarillotDelphine Lerouge
Sep 23, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John A VargoSushil Beriwal
May 2, 2013·Gynecologic Oncology·Aaron WagnerDavid Gaffney
Nov 26, 2014·PloS One·Jean-Emmanuel BibaultEric Lartigau
Nov 21, 2007·Radiation Medicine·Ryan M TierneyPerry W Grigsby
Dec 4, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ruijie YangJunjie Wang
Jul 1, 2008·Expert Review of Anticancer Therapy·Jessica L FiorelliJason D Wright

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.