Clinical outcomes after Descemet's stripping endothelial keratoplasty using donor corneas from children younger than 3 years

Clinical & Experimental Ophthalmology
Rong-Mei PengHong-Qiang Qu

Abstract

There is limited literature on paediatric donors in endothelial keratoplasty. This study investigated the efficacy of and appropriate paediatric donor age for Descemet's stripping endothelial keratoplasty (DSEK). Retrospective and observational case series. Thirty-eight consecutive patients underwent DSEK with paediatric donor corneas. The age of the donors ranged from 32 weeks gestation (premature neonate) to 3 years old. All donor consents were obtained from the parents. The causes of donor death included traffic accident, congenital heart disease and neonatal respiratory distress syndrome. The outcome measures included best-corrected visual acuity, endothelial cell loss and complications. Best-corrected visual acuity at last follow-up was >20/40 in 28 of 38 eyes (73.7%). The mean preoperative endothelial cell density of donor corneas was 4682 ± 520 cells/mm2 . The mean endothelial cell density of grafts was 3977 ± 556 cells/mm2 at 18 months postoperatively. Three lenticules from premature neonate donors exhibited severe contraction postoperatively. The edge of six lenticules from donors <1-year-old exhibited contraction in the early postoperative period and gradually flattened spontaneously. Graft detachment occurred in one ...Continue Reading

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Citations

Dec 19, 2020·International Ophthalmology Clinics·Moushmi PatilJodhbir S Mehta
Jan 6, 2021·The British Journal of Ophthalmology·Rashmi DeshmukhRasik B Vajpayee

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Methods Mentioned

BETA
dissection
confocal scanning microscopy

Software Mentioned

SPSS

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