Clinical outcomes after peripheral blood stem cell donation by related donors: a Dutch single-center cohort study

Transfusion
Johanna C Wiersum-OsseltonAnneke Brand

Abstract

Relatives donating peripheral blood stem cells (PBSCs) may be accepted for donation on less strict criteria than unrelated donors. We evaluated the occurrence of adverse events during procedure and follow-up, with a special focus on donors who would have been deferred as unrelated donors. All 268 related PBSC donors at our center (1996-2006) were included. Data were retrospectively collected from medical reports and standard follow-up. Health questionnaires were sent from 2007. Medical outcomes of donors, deferrable or eligible according to international criteria for unrelated donation, were compared. Forty donors (15%) would have been deferred for unrelated donation. Short-term adverse events occurred in 2% of procedures. Questionnaires were returned by 162 (60%) donors on average 7.5 years after donation, bringing total person-years of follow-up to 1278 (177 in deferrable donors). Nine malignancies and 14 cardiovascular events were reported. The incidence rate of cardiovascular events in eligible donors was 6.5 (95% confidence interval [CI], 2.5-12.3) per 1000 person-years compared to 44.9 (95% CI, 17.4-85.2) in deferrable donors; incidence rates of malignancies were 4.6 (1.4-9.6) and 24.0 (6.0-53.9) per 1000 person-years, re...Continue Reading

References

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Citations

Nov 26, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Chloe AnthiasPaul V O'Donnell
Nov 26, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Chloe AnthiasBronwen E Shaw
Sep 28, 2016·ACS Biomaterials Science & Engineering·Margaret Lashof-SullivanErin Lavik
Aug 27, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Menachem BitanMichael A Pulsipher
Aug 15, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nina WorelJörg P Halter
Mar 3, 2015·Bone Marrow Transplantation·C AnthiasB E Shaw
Feb 27, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Michele VaccaUNKNOWN SIdEM Board
Apr 12, 2014·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Annika KischMariette Bengtsson
Nov 12, 2014·Bone Marrow Transplantation·C AnthiasB E Shaw
Jul 7, 2017·Stem Cells International·Irene RiezzoEmanuela Turillazzi
Jun 15, 2021·Transplantation and Cellular Therapy·Cesar H Gutiérrez-AguirreOlga G Cantú-Rodríguez

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