Clinical outcomes after preimplantation genetic diagnosis of patients with Corino de Andrade disease (familial amyloid polyneuropathy)

Reproductive Biomedicine Online
Rita A LopesAlberto Barros

Abstract

The aim of this study was to determine whether patients with transthyretin-related hereditary amyloidosis (V30M), after transplantation or under tafamidis treatment, have normal gamete reproductive capacity. A retrospective analysis was carried out of all preimplantation genetic diagnosis (PGD) cycles performed in patients with the V30M mutation. The groups analysed were: total cases with V30M, female cases with V30M and male cases with V30M. Detailed demographic, stimulation, embryological, clinical and newborn outcomes were evaluated. Comparisons revealed that patients have a high likelihood of achieving a live birth per PGD treatment cycle (48%). This is the first large report on patients with the V30M mutation treated with PGD. The high rate of live birth obtained should represent a strong stimulus for patients to use PGD as it proved to be effective and safe. As a neurodegenerative disease that leads to death, it is of maximum importance that it could be eradicated using PGD in order to definitively avoid the transmission of the disease.

Citations

Dec 20, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Mónica InêsJoão Costa
Mar 14, 2018·Journal of Assisted Reproduction and Genetics·Jessica R ZoltonErin F Wolff
Jun 19, 2019·Nature Reviews. Neurology·David AdamsTeresa Coelho
Aug 11, 2020·Journal of Cardiac Failure·Ersilia M Defilippis, Michelle M Kittleson
May 14, 2021·Circulation. Heart Failure·Ersilia M DeFilippisMichelle M Kittleson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloidogenesis-associated Polyneuropathy

Amyloid deposits around nerves can damage and disrupt smooth information processing between the brain and organs. Here is the latest research on amyloidosis-associated polyneuropathies.

Related Papers

Fertility and Sterility
Moeen Al-SayedSerdar Coskun
Neurología : publicación oficial de la Sociedad Española de Neurología
A Jiménez EscrigL M Orensanz Muñoz
© 2022 Meta ULC. All rights reserved