Clinical Outcomes After Unilateral Adrenalectomy for Primary Aldosteronism.

JAMA Surgery
Wessel M C M VorselaarsInternational CONNsortium study group

Abstract

In addition to biochemical cure, clinical benefits after surgery for primary aldosteronism depend on the magnitude of decrease in blood pressure (BP) and use of antihypertensive medications with a subsequent decreased risk of cardiovascular and/or cerebrovascular morbidity and drug-induced adverse effects. To evaluate the change in BP and use of antihypertensive medications within an international cohort of patients who recently underwent surgery for primary aldosteronism. A cohort study was conducted across 16 referral medical centers in Europe, the United States, Canada, and Australia. Patients who underwent unilateral adrenalectomy for primary aldosteronism between January 2010 and December 2016 were included. Data analysis was performed from August 2017 to June 2018. Unilateral disease was confirmed using computed tomography, magnetic resonance imaging, and/or adrenal venous sampling. Patients with missing or incomplete preoperative or follow-up data regarding BP or corresponding number of antihypertensive medications were excluded. Clinical success was defined based on postoperative BP and number of antihypertensive medications. Cure was defined as normotension without antihypertensive medications, and clear improvement as...Continue Reading

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Citations

May 30, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Takanobu UtsumiHiroyoshi Suzuki
Nov 14, 2019·World Journal of Surgery·Fredrik SellgrenAndreas Muth
Sep 16, 2020·Journal of Human Hypertension·Maurizio CesariGian Paolo Rossi
Jul 5, 2019·World Journal of Surgery·Wessel M C M VorselaarsUNKNOWN International CONNsortium Study Group
Aug 28, 2020·The Journal of Clinical Hypertension·Hexuan ZhangUNKNOWN Chongqing Endocrine Hypertension Collaborative Team
Jul 29, 2019·Current Cardiology Reports·Gregory L Hundemer
Dec 12, 2019·Current Treatment Options in Cardiovascular Medicine·Jamie S Hirsch, Susana Hong
Dec 17, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Christina LobergLars Schimmöller
Nov 13, 2020·The Journal of Clinical Endocrinology and Metabolism·Davis SamAlexander A Leung
Aug 25, 2020·Current Opinion in Endocrine and Metabolic Research·Nicholas Yozamp, Anand Vaidya
May 20, 2020·The Canadian Journal of Cardiology·Davis SamAlexander A Leung
Dec 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Gregory A KlineBenny So
May 18, 2021·Annals of Medicine and Surgery·Diederik P D SuurdUNKNOWN International CONNsortium Study Group
Dec 28, 2021·American Journal of Hypertension·D SamA A Leung

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