Clinical outcomes among low-titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation

Transfusion
J N SeheultMark H Yazer

Abstract

The serological safety of transfusing ≤4 units of low titer group O whole blood (LTOWB) in civilian trauma patients has been demonstrated. This study investigated clinical outcomes of LTOWB recipients compared to patients who received only conventional blood components during their resuscitation. A retrospective analysis of trauma patients' medical records who received LTOWB during the first 24 hours of their admission was performed. Using a 12-parameter propensity matching strategy, LTOWB recipients were matched to other patients who received at least one red blood cell (RBC) unit during their first 24 hours of admission but not LTOWB. The primary outcomes were mortality and blood use. A total of 135 patients who received LTOWB (median 2 units) were matched to 135 patients who received conventional components. There were no significant differences in the matching parameters between the groups. There were no significant differences in outcomes between the conventional component and LTOWB groups: median (interquartile range) in-hospital mortality, 24.4% vs. 18.5% (respectively, p = 0.24); 24-hour mortality, 12.6% vs. 8.9% (respectively, p = 0.33). The hospital and intensive care unit lengths of stay were not significantly differ...Continue Reading

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Citations

Aug 26, 2018·Transfusion·John B Holcomb, Donald H Jenkins
Jan 30, 2019·Current Opinion in Anaesthesiology·Corey Scher, Robert Mansky
Apr 14, 2019·Transfusion·Pampee P Young, P Dayand Borge
Apr 30, 2019·The Journal of Trauma and Acute Care Surgery·Caroline S ZhuDonald H Jenkins
Aug 30, 2019·The Journal of Trauma and Acute Care Surgery·Jason L SperryKenji Inaba
Aug 8, 2019·The Journal of Trauma and Acute Care Surgery·Joshua P HazeltonJohn Porter
Oct 2, 2019·Current Opinion in Critical Care·Adil M Abuzeid, Terence O'Keeffe
Oct 30, 2019·European Journal of Haematology·Patricia LiuJoseph Shatzel
May 1, 2020·Military Medicine·Marshall BahrMark H Yazer
Jun 2, 2020·Transfusion·Bryon JacksonMagali J Fontaine
Apr 18, 2020·The Journal of Trauma and Acute Care Surgery·Joo-Yeun OhRakesh P Patel
Jun 24, 2020·The Journal of Trauma and Acute Care Surgery·Jared Robert GallaherMartin Schreiber
Oct 2, 2020·Journal of the American College of Emergency Physicians Open·Ellen CroweHenry E Wang
Jun 28, 2019·The Journal of Trauma and Acute Care Surgery·Caroline S ZhuDonald H Jenkins
Aug 27, 2019·Critical Care Medicine·Casey A CableDavid J Murphy
Aug 30, 2019·The Journal of Trauma and Acute Care Surgery·James WilliamsBryan A Cotton
Sep 16, 2020·Internal and Emergency Medicine·Mario CrucianiGiancarlo Maria Liumbruno
Aug 4, 2020·The Journal of Trauma and Acute Care Surgery·Kamil HannaBellal Joseph
Oct 6, 2020·The Journal of Trauma and Acute Care Surgery·Andrew D FisherStacy A Shackelford
Mar 1, 2019·Current Opinion in Anaesthesiology·Robert Mansky, Corey Scher
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Nov 24, 2019·Journal of the American College of Surgeons·Charlie J NederpeltHaytham Ma Kaafarani
Nov 7, 2020·Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses·Tiffany AlleyChristopher T Clark
Apr 3, 2021·Colombia médica : CM·Juan Carlos Salamea-MolinaJuan Carlos Puyana
Apr 16, 2021·Military Medicine·Craig D NowadlySteven G Schauer
Jun 19, 2021·Transfusion·Justin E Richards, Bryon P Jackson
Jul 17, 2021·Transfusion·Michael Adam MeledeoAndrew P Cap
Aug 31, 2021·Platelets·Norman F LucAnirban Sen Gupta
Oct 27, 2021·Advanced Emergency Nursing Journal·Allison R JonesHenry E Wang
Feb 12, 2020·Injury·Jonathan Copp, Jonathan G Eastman

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