Clinical outcomes and cardiovascular responses to exercise training in heart failure patients with preserved ejection fraction: a systematic review and meta-analysis

Journal of Applied Physiology
Gudrun DiebergNeil Smart

Abstract

Exercise training induces physical adaptations for heart failure patients with systolic dysfunction, but less is known about those patients with preserved ejection fraction. To establish whether exercise training produces changes in peak V̇o2 and related measures, quality of life, general health, and diastolic function in heart failure patients with preserved ejection fraction. We conducted a MEDLINE search (1985 to October 10, 2014), for exercise-based rehabilitation trials in heart failure, using search terms "exercise training, heart failure with preserved ejection fraction, heart failure with normal ejection fraction, peak V̇o₂, and diastolic heart dysfunction". Seven intervention studies were included providing a total of 144 exercising subjects and 114 control subjects, a total of 258 participants. Peak V̇o₂ increased by a mean difference (MD) 2.13 ml·kg(-1)·min(-1) [95% confidence interval (CI) 1.54 to 2.71, P < 0.00001] in exercise training vs. sedentary control, equating to a 17% improvement from baseline. The corresponding data are provided for the following exercise test variables: V̇e/V̇co₂ slope, MD 0.85 ml·kg(-1)·min(-1) (95% CI 0.05 to 1.65, P = 0.04); maximum heart rate, MD 5.60 beats per minute (95% CI 3.95 to ...Continue Reading

References

Jul 18, 1992·BMJ : British Medical Journal·J E BrazierL Westlake
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 15, 2004·Heart & Lung : the Journal of Critical Care·Rebecca A GaryRobert McMurray
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Nov 9, 2006·JAMA : the Journal of the American Medical Association·Francesca BursiVéronique L Roger
Jul 27, 2010·The Open Cardiovascular Medicine Journal·Filippo Maria SarulloPietro Di Pasquale
Aug 6, 2010·European Journal of Heart Failure·Carolyn S P LamRamachandran S Vasan
Jul 27, 2011·Arquivos brasileiros de cardiologia·Ricardo Fontes-Carvalho, Adelino Leite-Moreira
Oct 19, 2011·Medicine and Science in Sports and Exercise·Alberto Jorge AlvesJosé Oliveira
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jul 19, 2013·European Journal of Preventive Cardiology·Patricia PalauJulio Núñez
Nov 5, 2013·Journal of the American College of Cardiology·Elisabeth Kraigher-KrainerUNKNOWN PARAMOUNT Investigators
Dec 12, 2013·International Journal of Cardiology·Hashbullah IsmailNeil A Smart
Mar 4, 2015·International Journal of Evidence-based Healthcare·Neil A SmartGudrun Dieberg

❮ Previous
Next ❯

Citations

Aug 4, 2016·Journal of Neurotrauma·Katharine D CurrieAndrei V Krassioukov
May 19, 2017·Nature Reviews. Cardiology·Andrew J Stewart CoatsRoss Arena
May 8, 2018·Cardiology in Review·Wilbert S Aronow, Tatyana A Shamliyan
Feb 27, 2016·F1000Research·Michael S Kapiloff, Craig A Emter
Mar 21, 2018·Current Treatment Options in Cardiovascular Medicine·Chayakrit Krittanawong, Marrick L Kukin
Nov 26, 2019·Journal of Cardiopulmonary Rehabilitation and Prevention·Wesley J TuckerCorey R Tomczak
Jun 5, 2019·Current Heart Failure Reports·Michael Johannes SchindlerMartin Halle
Jun 14, 2020·Journal of Clinical Medicine·Venturini EGiallauria F
Sep 28, 2018·Current Cardiology Reports·Mara PaneroniMassimo Venturelli
Apr 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·J R CaldasL A Hajjar
Sep 5, 2018·Current Heart Failure Reports·Wesley J TuckerDaniel E Forman
Nov 24, 2017·American Journal of Physiology. Heart and Circulatory Physiology·David C AndradeRodrigo Del Rio
Jun 23, 2018·Frontiers in Cardiovascular Medicine·Stephen C Kolwicz
May 1, 2020·Journal of Clinical Medicine·Anna Di LorenzoFrancesco Giallauria
Jan 11, 2020·Journal of Sport and Health Science·Shanshan GuoTiemin Liu
Mar 20, 2021·Journal of the American College of Cardiology·Biykem BozkurtUNKNOWN ACC’s Heart Failure and Transplant Section and Leadership Council
Aug 24, 2021·Frontiers in Cardiovascular Medicine·Andrea PassantinoMaria Teresa La Rovere
Sep 21, 2021·Heart Failure Reviews·Stuart FisherMelissa J Pearson
Nov 2, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Francesco GiallauriaCarmine Morisco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.