Clinical outcomes and risk factors for severe COVID-19 in patients with haematological disorders receiving chemo- or immunotherapy

British Journal of Haematology
Thomas A FoxKirit M Ardeshna

Abstract

Haematology patients receiving chemo- or immunotherapy are considered to be at greater risk of COVID-19-related morbidity and mortality. We aimed to identify risk factors for COVID-19 severity and assess outcomes in patients where COVID-19 complicated the treatment of their haematological disorder. A retrospective cohort study was conducted in 55 patients with haematological disorders and COVID-19, including 52 with malignancy, two with bone marrow failure and one immune-mediated thrombotic thrombocytopenic purpura (TTP). COVID-19 diagnosis coincided with a new diagnosis of a haematological malignancy in four patients. Among patients, 82% were on systemic anti-cancer therapy (SACT) at the time of COVID-19 diagnosis. Of hospitalised patients, 37% (19/51) died while all four outpatients recovered. Risk factors for severe disease or mortality were similar to those in other published cohorts. Raised C-reactive protein at diagnosis predicted an aggressive clinical course. The majority of patients recovered from COVID-19, despite receiving recent SACT. This suggests that SACT, where urgent, should be administered despite intercurrent COVID-19 infection, which should be managed according to standard pathways. Delay or modification of ...Continue Reading

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Citations

Nov 23, 2020·British Journal of Haematology·Marquita CamilleriKwee Yong
Nov 21, 2020·British Journal of Haematology·Karolina AkinosoglouCharalambos Gogos
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georgios ChamilosDimitrios P Kontoyiannis
Jan 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georgios ChamilosDimitrios P Kontoyiannis
Dec 23, 2020·American Journal of Infection Control·Gina CahillNicholas L Rider
Oct 27, 2020·British Journal of Haematology·Adrien MirouseElie Azoulay
Oct 27, 2020·British Journal of Haematology·Thomas A FoxKirit M Ardeshna
Jun 4, 2021·World Journal of Virology·John Charles Riches
Jul 14, 2021·Future Oncology·Robin ParkAnup Kasi
Jul 14, 2021·Transplantation and Cellular Therapy·Muhammad Umair MushtaqJoseph P McGuirk

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