Clinical outcomes associated with high, intermediate, and low rates of failed extubation in an intensive care unit

Journal of Critical Care
Siddhartha G KapnadakAjeet G Vinayak

Abstract

Extubation failure is associated with adverse outcomes in mechanically ventilated patients, and it is believed that high rates of failed planned extubation (FPE) should be avoided. However, many believe that very low rates may also correlate with adverse outcomes if resulting from overly conservative weaning practices. We examined the relationship between the percentage of FPE (%FPE) and associated outcomes, with the aim of elucidating a favorable middle range. A total of 1395 extubations were analyzed in mechanically ventilated subjects. Monthly %FPE values were separated into tertiles. Ventilator-free days (VFDs), intensive care unit-free days (IFDs), and mortality were compared among tertiles. Monthly %FPE tertiles were as follows: low, less than 7%; intermediate, 7% to 15%; and high, greater than 15%. There were significant differences in VFDs and IFDs by tertile from low to high (VFDs: low, 11.8; intermediate, 12.1; high, 9.9 [P = .003]; IFDs: low, 10.5; intermediate, 10.7; high, 9.0 [P = .033]). Post hoc comparisons demonstrated significant differences between the middle and high tertiles for both VFDs and IFDs. Although exact rates may vary depending on setting, this suggests that a high %FPE (>15) should be avoided in t...Continue Reading

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Citations

Aug 11, 2015·Journal of Critical Care·Aracely Silva-CruzNilton Yhuri Carreazo
Sep 4, 2015·Journal of Critical Care·Siddhartha G KapnadakAjeet G Vinayak
May 18, 2016·Critical Care Medicine·Neil MacIntyre
Mar 16, 2017·American Journal of Respiratory and Critical Care Medicine·Neil MacIntyre
Jul 25, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Samer Abu-SultanehChristopher W Mastropietro
Jun 23, 2018·Physiological Measurement·Jessica Keim-MalpassMatthew T Clark
Jan 20, 2021·Journal of Intensive Care Medicine·Suraj TrivediMichael D Maile

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