Abstract
The study sought to determine whether rapid access to medical care and reperfusion results in a better prognosis in patients with in-hospital compared with out-of-hospital stent thrombosis (ST) in patients with ST-segment elevation myocardial infarction (STEMI) in the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial. Whether the prognosis of in-hospital and out-of-hospital ST are similar is uncertain, with conflicting data reported from prior studies. A total of 3,602 STEMI patients undergoing primary percutaneous coronary intervention (PCI) were randomized to bivalirudin (n = 1,800) versus unfractionated heparin (UFH) plus a glycoprotein IIb/IIIa inhibitor (GPI) (UFH+GPI; n = 1,802). Stents were implanted in 3,202 patients, 156 (4.9%) of whom developed Academic Research Consortium definite/probable ST during 3-year follow-up. We investigated the 1-year clinical outcomes after ST in 54 patients with in-hospital ST compared with 102 patients with out-of-hospital ST. One year after the ST event, patients with in-hospital compared with out-of-hospital ST had significantly greater mortality (27.8% vs. 10.8%, p < 0.01); most deaths in both groups occurred within 1 week of the...Continue Reading
References
Jan 1, 1997·Journal of the American College of Cardiology·I MoussaA Colombo
Jun 25, 2003·Circulation·Edouard CheneauRon Waksman
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Feb 21, 2006·Journal of the American College of Cardiology·Sunil V RaoRobert A Harrington
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
May 24, 2008·The New England Journal of Medicine·Gregg W StoneUNKNOWN HORIZONS-AMI Trial Investigators
Jul 1, 2008·American Heart Journal·Roxana MehranGregg W Stone
May 8, 2009·The New England Journal of Medicine·Gregg W StoneUNKNOWN HORIZONS-AMI Trial Investigators
Jun 23, 2010·Circulation·Takeshi KimuraUNKNOWN RESTART Investigators
Apr 13, 2011·Circulation·George D DangasUNKNOWN Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial Investigators
Jun 28, 2011·JACC. Cardiovascular Interventions·Roxana MehranGregg W Stone
Citations
Mar 19, 2014·The American Journal of Cardiology·Binita ShahSteven P Sedlis
Jan 23, 2016·European Heart Journal·Tullio Palmerini, Gregg W Stone
Dec 20, 2015·European Heart Journal·Alex SirkerDavid Hildick-Smith
Jan 1, 2012·Scientifica·Mun K Hong
Feb 22, 2013·Thrombosis and Haemostasis·M A BrouwerF W A Verheugt
Nov 29, 2013·Thrombosis and Haemostasis·Victor L SerebruanyJames J DiNicolantonio
Feb 13, 2015·Thrombosis and Haemostasis·Raffaele PiccoloGennaro Galasso
Mar 19, 2013·Journal of the American College of Cardiology·Simon R Dixon, Robert D Safian
Mar 21, 2017·The American Journal of Cardiology·Thea C GodschalkJurriën M Ten Berg
May 5, 2017·Cardiology·Junhua GeJian Li
Jan 27, 2015·JACC. Cardiovascular Interventions·Eliano Pio NavareseMarco Valgimigli
Jan 18, 2017·PloS One·Haiyan XuXiongwei Xie
Jul 3, 2013·Therapeutic Advances in Cardiovascular Disease·Ana Muñiz-LozanoDominick J Angiolillo
Jul 4, 2016·JACC. Cardiovascular Interventions·Sorin J BrenerGregg W Stone
Apr 19, 2015·European Journal of Medical Research·Jianfeng LvLuxiang Chi
Oct 22, 2014·Open Heart·Chun Shing KwokMamas A Mamas
Jan 24, 2020·Cardiovascular Intervention and Therapeutics·Antonio MangieriAntonio Colombo
Feb 13, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·K Anette FiedlerAdnan Kastrati
Sep 1, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasushi FukuTsuyoshi Goto
Jun 24, 2020·Cardiovascular Drugs and Therapy·Jinying ZhouHongbing Yan
Jan 14, 2021·Cardiovascular Intervention and Therapeutics·Shoichi KuramitsuTakeshi Kimura
May 19, 2021·Circulation. Cardiovascular Quality and Outcomes·Jennifer ZhouDion Stub