Clinical Outcomes From Cultivated Allogenic Stem Cells vs. Oral Mucosa Epithelial Transplants in Total Bilateral Stem Cells Deficiency

Frontiers in Medicine
Ovidiu Samoila, Diana Gocan

Abstract

Total bilateral limbal stem cell deficiency results from various pathologies, from burns (either chemical or physical) to Sjogren Syndrome, aniridia or ocular cicatricial pemphigoid. After the loss of stem cells, normal corneal epithelium is replaced by a more opaque and vascularized conjunctival epithelium, causing loss of vision. After 1997, cultivation techniques for limbal stem cells became possible. In parallel, cultivation techniques for oral mucosa epithelial cells were also available. The aim of our review was to summarize the clinical outcomes following allogenic cultured limbal stem cell transplant (allogenic CLET), and on the other hand, oral mucosa derived epithelium transplant (cultivated oral mucosa epithelial transplant-COMET or cultivated autologous oral mucosal epithelial cell sheet-CAOMECS), in the case of total bilateral limbal stem cell loss. Thirty studies matching the inclusion criteria were found. The clinical improvement in both methods was reported similar, with percentages higher than 50% of the treated cases. However, the comparison between studies was difficult to achieve due to the lack of a universal and objective grading tool for assessing post-operative results. The definition of clinical improve...Continue Reading

References

May 1, 1989·Ophthalmology·K R Kenyon, S C Tseng
Sep 17, 2004·The New England Journal of Medicine·Kohji NishidaYasuo Tano
Jan 26, 2007·Investigative Ophthalmology & Visual Science·Wei LiScheffer C G Tseng
Oct 10, 2007·Archives of Ophthalmology·Motoko KawashimaJun Shimazaki
Jun 17, 2008·Ophthalmology·Alex J ShorttJulie T Daniels
May 22, 2009·Investigative Ophthalmology & Visual Science·Hung-Chi Jesse ChenDavid Hui-Kang Ma
Oct 12, 2012·Clinical Ophthalmology·Pinnita PrabhasawatNattaporn Tesavibul
Oct 23, 2012·Ophthalmology·Chie SotozonoShigeru Kinoshita
Mar 5, 2014·Journal of Translational Medicine·Nadia ZakariaMarie-Jose Tassignon
Sep 11, 2014·Stem Cells Translational Medicine·Charanya RamachandranDorairajan Balasubramanian
Sep 19, 2014·Stem Cells Translational Medicine·Indumathi MariappanVirender Singh Sangwan
Feb 7, 2015·Tissue Engineering. Part B, Reviews·Sara LlamesMarcela del Río
Jul 2, 2015·World Journal of Stem Cells·Aline Lütz de Araujo, José Álvaro Pereira Gomes
Oct 10, 2015·BioMed Research International·Dariusz DobrowolskiPasquale Aragona
Oct 10, 2015·BioMed Research International·Beatriz E RamírezMargarita Calonge
Apr 22, 2016·Clinical Ophthalmology·Marwan Raymond AtallahGuillermo Amescua
Jun 18, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peng ChenLixin Xie
Nov 28, 2017·Seminars in Ophthalmology·Jia Yin, Ula Jurkunas
Dec 31, 2017·EMBO Molecular Medicine·Robert E HyndsSam M Janes
Oct 26, 2018·Stem Cell Research & Therapy·Koushik ChakrabartyArkasubhra Ghosh
Dec 24, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Margarita CalongeJosé M Herreras
Jan 29, 2019·Stem Cells Translational Medicine·John D M CampbellBaljean Dhillon
Apr 21, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Junyi WangLixin Xie
May 3, 2019·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Kiranjit K BainsAndrew J Quantock
Sep 6, 2019·Stem Cells Translational Medicine·Vincent M BorderieHélène Rouard

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Citations

Jan 25, 2021·Experimental Eye Research·Ruchi ShahAlexander V Ljubimov
Oct 28, 2020·International Journal of Molecular Sciences·Kasem TheerakittayakornRangsun Parnpai
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Aug 28, 2021·Biomedicines·Ovidiu Samoila, Lacramioara Samoila

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Methods Mentioned

BETA
biopsy
biopsies
confocal microscopy
PCR

Software Mentioned

CLET
CAOMECS
COMEC
COMET

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