Clinical outcomes in ocular pythiosis patients treated with a combination therapy protocol in Thailand: A prospective study.

Medical Mycology
Nitipong PermpalungAriya Chindamporn

Abstract

Ocular pythiosis is the second most common form of human pythiosis, and the rates of evisceration/enucleation in Thailand are 55-79%. This prospective study was conducted to evaluate treatment outcomes of the combination therapy protocol and the potential use of serum (1→3)-β-glucan (BG) and Pythium insidiosum-specific antibody (Pi-Ab) as an aid to diagnosis and monitoring of ocular pythiosis. Thirty patients were enrolled in the study and 14 (non-globe salvage) required evisceration/enucleation. The globe salvage group was significantly younger, and first ocular surgeries were performed significantly sooner than in the non-globe salvage group. Serum BG and Pi-Ab levels were similar among the 2 groups over time. In vitro susceptibility testing of antifungal agents revealed relatively high minimum inhibitory concentrations and lack of synergistic effect. Serum BG and Pi-Ab would not be useful in diagnosis and monitoring of ocular pythiosis. Until effective antimicrobial agents are discovered, ocular surgeries are still the mainstay therapy in Thailand.

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Jun 1, 2018·Journal of Clinical Microbiology·Navaporn WorasilchaiAriya Chindamporn

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Citations

Feb 6, 2020·Antimicrobial Agents and Chemotherapy·Navaporn WorasilchaiNitipong Permpalung
Dec 18, 2019·Mycopathologia·Nitipong PermpalungAriya Chindamporn
Mar 3, 2020·PeerJ·Maria Nina ChitasombatTheerapong Krajaejun
Dec 2, 2020·Journal de mycologie médicale·Z Mar HtunT Krajaejun
Nov 7, 2020·Experimental Eye Research·Lalit Kishore AhirwarBhupesh Bagga
Jun 9, 2020·Ophthalmology·Bhupesh BaggaSanchita Mitra

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