Clinical outcomes in patients with hepatitis D, cirrhosis and persistent hepatitis B virus replication, and receiving long-term tenofovir or entecavir

Alimentary Pharmacology & Therapeutics
Giuseppina BrancaccioGiovanni B Gaeta

Abstract

Suppression of hepatitis B virus (HBV) replication with nucelos(t)ide analogues should be considered for patients with chronic hepatitis D virus (HDV) infection and ongoing HBV replication. To verify the clinical outcome after long-term entecavir or tenofovir treatment in patients with advanced fibrosis/cirrhosis, ineligible to peg-interferon therapy. Patients were prospectively followed-up at 3-6 month intervals; measured outcomes were decompensation, hepatocellular carcinoma (HCC), liver transplant and liver related death. HBV monoinfected patients receiving the same treatment served as reference after 1:1 matching by age, gender, platelet count, albumin level, bilirubin and INR. 56 HDV patients (48 with cirrhosis; median follow-up 50 months) were enrolled; all achieved HBV DNA suppression. Death or liver transplant occurred in 19 patients, with a rate (n/1000 patient-months) of 2.92 in HDV patients vs 0.38 in HBV monoinfected patients (P < 0.001); similarly, decompensation occurred at a rate of 1.53 vs 0.13 (P = 0.015), respectively, and the rate of HCC was almost thrice in HDV cohort (3.12 vs 1.12; P = 0.02) Platelet count, Child-Pugh score and marginally HDV infection were associated with HCC development. Patients with HDV...Continue Reading

References

Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Jun 26, 1999·Gastroenterology·F RosinaM Rizzetto
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V Di MarcoA Craxì
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G B GaetaM Rizzetto
Aug 31, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Grazia Anna NiroMario Rizzetto
Aug 31, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Corinne CastelnauElyanne Gault
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Heiner WedemeyerMichael P Manns
Sep 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni B GaetaAlfonso Mele
Dec 22, 2007·Journal of Medical Virology·Timothy J S CrossPhillip M Harrison
Mar 17, 2009·Journal of Hepatology·Mario Rizzetto
Aug 31, 2010·Journal of Hepatology·Grazia Anna NiroAngelo Andriulli
Jan 28, 2011·The New England Journal of Medicine·Heiner WedemeyerUNKNOWN HIDIT Study Group
Apr 23, 2011·Lancet·Sarah A HughesPhillip M Harrison
Jan 26, 2012·Alimentary Pharmacology & Therapeutics·C TriantosA Burroughs
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
May 11, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gökhan KabaçamCihan Yurdaydin
Jul 16, 2013·Journal of Hepatology·Emanuel K ManesisGiota Touloumi
Mar 4, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin HeidrichUNKNOWN HIDIT-1 Study Group
Mar 19, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·José Vicente Fernández-MonteroVincent Soriano
Apr 17, 2016·Journal of Hepatology·Camille Sureau, Francesco Negro
Oct 18, 2016·Journal of Hepatology·Charles BéguelinUNKNOWN Swiss HIV Cohort Study
Oct 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anika WrankeHeiner Wedemeyer
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jun 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George V PapatheodoridisPietro Lampertico
Oct 1, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Anika WrankeUNKNOWN Hepatitis Delta International Network
Feb 23, 2018·Seminars in Liver Disease·Mario Rizzetto
Jun 3, 2018·Molecular Cancer Research : MCR·Giacomo DiazPatrizia Farci
Dec 17, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Mariantonietta PisaturoNicola Coppola

❮ Previous
Next ❯

Citations

Nov 14, 2019·Alimentary Pharmacology & Therapeutics·Adriana PalomMaria Buti
Dec 28, 2019·Alimentary Pharmacology & Therapeutics·Bao-Hong YuanRu-Hong Li
Jan 29, 2020·Alimentary Pharmacology & Therapeutics·Alberto FerrareseFrancesco Paolo Russo
Jan 29, 2020·Alimentary Pharmacology & Therapeutics·Giuseppina Brancaccio, Giovanni B Gaeta
May 14, 2020·Infectious Diseases·Giuseppina BrancaccioUmberto Cillo
Jul 25, 2020·Journal of Viral Hepatitis·Anika WrankeCihan Yurdaydin
Feb 23, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Maria ButiRafael Esteban
May 1, 2021·Viruses·Eirini D TseligkaFrancesco Negro
Jul 10, 2021·World Journal of Gastroenterology : WJG·Grazia A NiroMarilena Durazzo
Sep 7, 2021·Expert Opinion on Investigational Drugs·Bilal Asif, Christopher Koh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.