Clinical Outcomes in Patients With Nonobstructive, Labile, and Obstructive Hypertrophic Cardiomyopathy

Journal of the American Heart Association
Dai-Yin LuTheodore P Abraham

Abstract

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disease characterized by varying degrees of left ventricular outflow tract obstruction. In a large cohort, we compare the outcomes among 3 different hemodynamic groups. We prospectively enrolled patients fulfilling standard diagnostic criteria for HCM from January 2005 to June 2015. Detailed phenotypic characterization, including peak left ventricular outflow tract pressure gradients at rest and after provocation, was measured by echocardiography. The primary outcome was a composite cardiovascular end point, which included new-onset atrial fibrillation, new sustained ventricular tachycardia/ventricular fibrillation, new or worsening heart failure, and death. The mean follow-up was 3.4±2.8 years. Among the 705 patients with HCM (mean age, 52±15 years; 62% men), 230 with obstructive HCM were older and had a higher body mass index and New York Heart Association class. The 214 patients with nonobstructive HCM were more likely to have a history of sustained ventricular tachycardia/ventricular fibrillation and implantable cardioverter defibrillator implantation. During follow-up, 121 patients experienced a composite cardiovascular end point. Atrial fibrillation occurred ...Continue Reading

References

Jan 15, 1991·The American Journal of Cardiology·L A AronJ J Kellermann
Jan 24, 2003·The New England Journal of Medicine·Martin S MaronBarry J Maron
Sep 12, 2003·The New England Journal of Medicine·Franco CecchiPaolo G Camici
May 28, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Tomoko TaniShigefumi Morioka
Jun 15, 2004·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Jan 5, 2005·Journal of the American College of Cardiology·Allison M PritchettMargaret M Redfield
May 15, 2007·Journal of the American College of Cardiology·Cheuk-Man YuJae K Oh
Nov 28, 2007·Circulation·Theodore P AbrahamHsin-Yueh Liang
Jun 16, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jeffrey B GeskeSteve R Ommen
Oct 8, 2009·Circulation. Heart Failure·Martin S MaronBarry J Maron
Aug 7, 2010·Journal of the American College of Cardiology·Rory O'HanlonSanjay K Prasad
Apr 26, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehUNKNOWN Society of Cardiovascular Computed Tomography
Feb 9, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paco E BravoFrank M Bengel
Jul 7, 2014·Journal of the American College of Cardiology·Barry J MaronMartin S Maron
Aug 21, 2014·Circulation. Cardiovascular Genetics·Barry J Maron, Martin S Maron
Nov 28, 2014·European Heart Journal Cardiovascular Imaging·Jesús PeteiroAlfonso Castro-Beiras
May 9, 2015·Journal of the American College of Cardiology·Barry J MaronMartin S Maron
Mar 6, 2016·Mayo Clinic Proceedings·Virginia B HeblJeffrey B Geske
Mar 26, 2016·Journal of the American College of Cardiology·Martin S MaronBarry J Maron
Mar 26, 2016·Journal of the American College of Cardiology·Perry M Elliott
Jun 28, 2016·International Journal of Cardiology·Quirino CiampiEugenio Picano
Nov 1, 2016·Heart·Oliver P GuttmannUNKNOWN Hypertrophic Cardiomyopathy Outcomes Investigators
Feb 7, 2017·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patrizio LancellottiAlbert Varga

❮ Previous
Next ❯

Citations

Oct 26, 2018·Circulation·Perry Elliott
Jan 16, 2020·Internal and Emergency Medicine·Ziqiong WangSen He
Dec 2, 2020·Journal of Patient-reported Outcomes·Erica ZaiserMatthew Reaney
Dec 11, 2020·BMC Cardiovascular Disorders·Lazar VelickiIacopo Olivotto
Jan 21, 2021·The Journal of Thoracic and Cardiovascular Surgery·Hao CuiSteve R Ommen
Jun 1, 2021·Frontiers in Cardiovascular Medicine·Ahmed S FahmyReza Nezafat
Jun 25, 2021·Scientific Reports·Styliani VakrouM Roselle Abraham

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

STATA

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.