Clinical outcomes of botulinum toxin injection in patients with cerebral palsy and esotropia

Strabismus
Ahmad AmeriSimindokht Hosseini

Abstract

To assess the efficacy of botulinum toxin (Novotox) injection in patients with cerebral palsy (CP) and esotropia. In a non-comparative, prospective interventional case series botulinum toxin injection was done in 44 patients with CP and esotropia. A single dose of botulinum toxin was injected in both medial rectus muscles of all patients and was repeated in 12 patients. Angle of deviation within 10 prism diopters (PD) of orthotropia was defined as a successful outcome. Forty-four patients (21 males) with the mean age of 47.56 ± 35.86 months were included in the study. The mean esotropia in all patients was 52.27 ± 18.40 PD (25-123 PD). The range of follow-up was 12-24 months. Thirty patients (68.18%) were treated successfully one year after surgery. The rates of success, consecutive exotropia, and residual esotropia were 61.4%, 13.63%, and 25% in the last follow-up, respectively. The logistic regression showed statistically significant results between success result and lower age, higher pre-injection deviation, one month post-injection deviation, and severe ptosis. Complications included subconjunctival hemorrhage and ptosis. Botulinum toxin injection is reasonably less invasive with light anesthesia, scar free, and a therapeu...Continue Reading

References

Nov 1, 1990·Ophthalmology·A B ScottD R Stager
Oct 1, 1985·The British Journal of Ophthalmology·J S ElstonP Clark
Jan 1, 1982·The British Journal of Ophthalmology·P Black
Jun 5, 1998·The British Journal of Ophthalmology·J Elston
May 9, 2006·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Zohar Habot-WilnerTamara Wygnanski-Jaffe
Nov 23, 2006·Arquivos brasileiros de oftalmologia·Mônica Fialho CronembergerHarley Edison do Amaral Bicas
Nov 3, 2009·Acta Ophthalmologica·Kirsten Baggesen, Håvard Magnus Arnljot
May 7, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Martin T SteinWilliam B Carey
May 11, 2010·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Alejandra G de Alba CampomanesGlorialicia Campomanes Eguiarte
Apr 26, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S HiromatsuS Fukunaga
Mar 17, 2012·Journal of Pediatric Ophthalmology and Strabismus·Harry PetrushkinSaurabh Jain

❮ Previous
Next ❯

Citations

Jun 27, 2017·Current Opinion in Ophthalmology·Marielle Mahan, J Mark Engel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.