Clinical Outcomes of Conversion Surgery after Neoadjuvant Chemotherapy in Patients with Borderline Resectable and Locally Advanced Unresectable Pancreatic Cancer: A Single-Center, Retrospective Analysis

Cancers
Changhoon YooSong Cheol Kim

Abstract

The clinical benefit and potential risks of conversion surgery after neoadjuvant chemotherapy (NACT) have not been fully investigated in patients with borderline resectable pancreatic cancer (BRPC) and locally advanced unresectable pancreatic cancer (LAPC). Therefore, this has been evaluated in a retrospective, prospective cohort-based analysis. Between October 2005 and April 2017, 135 patients (65 with BRPC and 70 with LAPC) received conversion surgery after NACT. Exploratory analysis to assess clinical outcomes in comparison with patients who underwent upfront surgery in the same time period (n = 359) was also conducted. NACT with gemcitabine-based regimens (including gemcitabine monotherapy, gemcitabine-capecitabine combination, and gemcitabine-erlotinib combination) was used in 69 patients (51%) and FOLFIRINOX in 66 patients (49%). The median overall survival (OS) and disease-free survival (DFS) from the time of surgery was 25.4 months (95% CI, 18.6⁻32.2 months) and 9.0 months (95% CI, 6.8⁻11.2 months), respectively. The median OS and progression-free survival from the initiation of NACT was 29.7 months (95% CI, 22.5⁻36.8 months) and 13.4 months (95% CI, 12.5⁻14.4 months), respectively. In the exploratory analysis, conversi...Continue Reading

References

Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory M HeestandAndrew M Lowy
Sep 29, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Moh'd KhushmanPeter J Hosein
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Sep 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ali A MokdadPatricio M Polanco
Jan 4, 2017·Surgery·Claudio BassiUNKNOWN International Study Group on Pancreatic Surgery (ISGPS)
Mar 11, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyu-Won JungUNKNOWN Community of Population-Based Regional Cancer Registries

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Citations

Aug 24, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chang-Il Kwon
Sep 29, 2020·Therapeutic Advances in Medical Oncology·Changhoon YooBaek-Yeol Ryoo
Apr 9, 2020·Cancer Immunology Research·Hyung-Seung JinYoon Park
Feb 4, 2021·Annals of Gastroenterological Surgery·Keinosuke IshidoTaiichi Wakiya
Jun 25, 2021·World Journal of Gastroenterology : WJG·Nikhil Gupta, Raghav Yelamanchi
Aug 14, 2021·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Sho HasegawaKensuke Kubota

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Methods Mentioned

BETA
surgical resection
pancreatectomy

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

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