Clinical outcomes of deep invasive submucosal colorectal cancer after ESD

Surgical Endoscopy
Daisuke WatanabeTakeshi Azuma

Abstract

Endoscopic submucosal dissection (ESD) is a reliable method that can replace surgery under certain conditions. However, limited information is available on the clinical course of T1b colorectal cancer (CRC) after ESD. The aim of the study was to clarify the feasibility of ESD for T1b CRC. Three hundred and two patients with 312 T1 CRC were identified in this retrospective cohort study. All patients were treated with ESD, other endoscopic treatments, or surgery. In this study, we (I) investigated the en bloc resection rate of ESD and (II) compared the overall survival (OS) rate for patients who underwent ESD with additional surgery (Group A) and surgery without upfront endoscopic resection (Group B) for T1b CRC. No significant differences were observed in the en bloc resection rates between T1b and T1a CRC (100 vs. 98.7%), but the en bloc R0 resection rate was significantly lower in T1b CRC than in T1a CRC (64.7 vs. 97.4%). Regarding complications, perforations occurred in 2.9% of patients with T1b CRC, which was not significantly different from the rate of 5.3% in patients with T1a CRC. No significant differences were observed in the OS or recurrence-free survival (RFS) curves between Groups A and B (OS rates at 5 years: 92.3 v...Continue Reading

References

Jun 16, 2010·Journal of Gastroenterology and Hepatology·Hisatomo IkeharaYoshitaka Murakami
May 25, 2011·International Journal of Colorectal Disease·Yasutoshi KobayashiKoji Kawakami
Dec 7, 2011·Journal of Gastroenterology and Hepatology·Koichi NakadoiKazuaki Chayama
Dec 13, 2012·Gastroenterology·Hiroaki IkematsuYutaka Saito
Jul 22, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shinji TanakaKazuaki Chayama
Feb 6, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shinji TanakaHisao Tajiri
Mar 19, 2015·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Dec 23, 2015·International Journal of Colorectal Disease·Naoki AsayamaKazuaki Chayama

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Citations

Oct 29, 2020·International Journal of Colorectal Disease·Yuan TianYongchen Ma
Dec 4, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hao DangJurjen J Boonstra
Sep 4, 2021·Journal of Gastroenterology and Hepatology·Yuki OkamotoShinji Tanaka

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