Clinical outcomes of direct-acting antiviral treatments for patients with hepatitis C after hepatocellular carcinoma are equivalent to interferon treatment

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Yuki TahataTetsuo Takehara

Abstract

It remains unclear how direct-acting antiviral (DAA) treatments influence hepatocellular carcinoma (HCC) recurrence and survival in comparison with interferon (IFN). In total, 338 patients with chronic hepatitis C virus (HCV) infection and previous HCC treatments who initiated IFN (N = 88, IFN group) or DAA treatment (N = 250, DAA group) from January 2005 to November 2017 at 23 hospitals and achieved sustained virologic response (SVR) were analyzed. Cumulative HCC recurrence and survival rates were compared between the two groups using propensity score (PS) matching. After PS matching, 63 patients were selected for each group. The cumulative HCC recurrence rates at 1 and 3 years were 20.6% and 34.6% in the IFN group and 19.2% and 43.0% in the DAA group, respectively; the difference in cumulative HCC recurrence rates between the two groups was not significant (P = 0.332). No significant differences in HCC recurrence patterns were observed between the two groups. Overall survival rates at 1 and 3 years were 100% and 96.6% in the IFN group and 100% and 96.4% in the DAA group, respectively; the difference in overall survival rates between the two groups was not significant (P = 0.132). No significant differences in HCC recurrence a...Continue Reading

References

Mar 8, 2006·World Journal of Gastroenterology : WJG·Masatoshi Makuuchi, Norihiro Kokudo
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Masatoshi AkamatsuMasao Omata
Nov 28, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masatoshi MakuuchiYoshio Yamaoka
Jul 28, 2010·Alimentary Pharmacology & Therapeutics·A K SingalB S Anand
May 28, 2011·Diabetes Care·David B SacksUNKNOWN Evidence-Based Laboratory Medicine Committee of the American Association for Clinical Chemistry
Jan 20, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masayuki SakaeShigefumi Suehiro
Jan 28, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norihiro KokudoMasatoshi Makuuchi
Mar 11, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kouji JokoNamiki Izumi
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Sashidhar ManthravadiPrashant Pandya
Jun 20, 2017·Journal of Hepatology·Hiroko NagataUNKNOWN Ochanomizu Liver Conference Study Group
Aug 10, 2017·Alimentary Pharmacology & Therapeutics·G CabibboUNKNOWN Rete Sicilia Selezione Terapia - HCV (RESIST-HCV)
Oct 17, 2017·Alimentary Pharmacology & Therapeutics·E OgawaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
Oct 20, 2018·Journal of Hepatology·Mizuki Nishibatake KinoshitaKazuhiko Koike
Apr 9, 2019·Journal of Hepatology·Giuseppe CabibboUNKNOWN Rete Sicilia Selezione Terapia – HCV (RESIST-HCV) and Italian Liver Cancer (ITA.LI.CA.) Group
Jul 25, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norihiro KokudoYutaka Matsuyama
Oct 15, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hansen DangMindie H Nguyen
Apr 17, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiro Asahina, UNKNOWN Drafting Committee for Hepatitis Management Guidelines, the Japan Society of Hepatology

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Citations

Oct 8, 2021·Alimentary Pharmacology & Therapeutics·Yuki TahataUNKNOWN Osaka Liver Forum

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