Clinical outcomes of hepatitis C treatment before and after kidney transplantation and its impact on time to transplant: A multicenter study

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
D M ChascsaB A Aqel

Abstract

Waitlist time for kidney transplantation is long but may be shortened with the utilization of hepatitis C positive allografts. We retrospectively reviewed the course of 36 hepatitis C positive patients awaiting kidney transplantation at 2 large centers within the same health system, with near-identical care delivery models with the exception of timing of hepatitis C treatment, to determine the impact of timing of hepatitis C treatment on access to transplant, waitlist time, and treatment efficacy and tolerability. The majority of patients had hepatitis C genotype 1a or 1b, and all received direct acting antiviral therapy with 100% treatment response. One patient underwent transplantation in the pretransplant treatment group. The 1-year transplantation rate was 12.5% vs 67.9% (P = .0013) in those treated posttransplantation. The median waitlist time in the posttransplant group was 122 (interquartile range [IQR] 21.5, 531.0) days, which was significantly shorter than the center's regional and national wait time. Pathologic review revealed no difference in allograft quality. Overall treatment related adverse events were not different between the 2 groups. A strategy of posttransplant hepatitis C treatment increased access to trans...Continue Reading

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Citations

Jul 11, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Naoki KawagishiIzumi Haga
Jun 1, 2019·Current Transplantation Reports·Luckmini LiyanageChristine M Durand
Sep 18, 2020·Journal of the American Society of Nephrology : JASN·Pascale KhairallahJae-Hyung Chang
Mar 13, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mary G BowringDorry L Segev
Jun 20, 2020·Disease-a-month : DM·Abhijay JalotaEdgar V Lerma
Feb 1, 2020·Transplantation Proceedings·Christini Takemi EmoriMaria Lucia Gomes Ferraz

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