Clinical outcomes of hepatitis C treatment in a prison setting: feasibility and effectiveness for challenging treatment populations.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Duncan Smith-Rohrberg MaruFrederick L Altice

Abstract

More than one-third of people in the United States with hepatic C virus (HCV) infection pass through the correctional system annually. Data are lacking on outcomes of treatment with pegylated interferon plus ribavirin (PEG-RBV) in correctional settings. During 2002-2006, we analyzed patients in the Connecticut Department of Correction who received PEG-RBV. We assessed the rates of sustained virological response, hospitalization, and use of medications to treat psychiatric disorders and anemia. Of 138 treatment-naive patients referred for treatment, 68 (49%) were approved. Overall, sustained virological response occurred in 47.1% of patients (for HCV genotype 1, 43.1%; for HCV genotypes 2 and 3, 58.8%). Only 9 patients (13%) discontinued treatment because of adverse effects. Multiple regression analysis revealed that not achieving a sustained virological response was correlated with HCV genotype 1 infection plus cirrhosis (adjusted odds ratio, 12.9; 95% confidence interval, 1.1-148) and baseline major depression (adjusted odds ratio, 3.4; 95% confidence interval, 1.01-11.6), but not with HIV infection, a baseline HCV RNA level >or=400,000 IU/mL, or black race. Compared with baseline, the rate of prescription of a new mood stabil...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jan 15, 1993·Annals of Internal Medicine·J B Glaser, R B Greifinger
Feb 12, 1999·Preventive Medicine·A SpauldingJ Rich
Feb 19, 2002·Annals of Internal Medicine·Yngve Falck-YtterArthur J McCullough
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 31, 2002·American Journal of Public Health·Theodore M HammettWilliam Rhodes
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Martin SchaeferKlaus Loeschke
Feb 1, 2003·Annals of Internal Medicine·Scott A AllenJosiah D Rich
Feb 1, 2003·Annals of Internal Medicine·Theodore M Hammett
Aug 9, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas T Dieterich, Jerry L Spivak
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Apr 15, 2004·Gastroenterology Clinics of North America·Nezam H Afdhal
Apr 15, 2004·Gastroenterology Clinics of North America·Peter Hauser
May 7, 2004·The American Journal of Gastroenterology·Richard K SterlingMitchell L Shiffman
Jul 28, 2004·The American Journal of Medicine·Matthew J HepburnEric J Lawitz
Jul 30, 2004·The New England Journal of Medicine·Jean-Michel Pawlotsky
Jul 30, 2004·The New England Journal of Medicine·Francesca J TorrianiUNKNOWN APRICOT Study Group
Jul 30, 2004·The New England Journal of Medicine·Raymond T ChungUNKNOWN AIDS Clinical Trials Group A5071 Study Team
Dec 15, 2004·Journal of Clinical Gastroenterology·Brian P Mulhall, Zobair Younossi
Dec 16, 2004·JAMA : the Journal of the American Medical Association·Fabrice CarratUNKNOWN ANRS HCO2 RIBAVIC Study Team
Jan 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephen ReschA David Paltiel
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Diana L Sylvestre
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gail MatthewsGregory J Dore
Mar 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brennan M R SpiegelFasiha Kanwal
Jun 16, 2005·Journal of Gastroenterology and Hepatology·Richard HallinanGregory J Dore
Sep 1, 2005·American Journal of Public Health·John FarleyTheresa A Farley
Sep 2, 2005·AIDS·Therese M Hesketh, Li Lu
Sep 27, 2005·Journal of Substance Abuse Treatment·Diana L SylvestreMarc N Gourevitch
Nov 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Diana L Sylvestre
Mar 2, 2006·Psychosomatics·Muhamad Aly RifaiBrian J Van der Linden
Apr 11, 2006·Psychiatric Services : a Journal of the American Psychiatric Association·Muhamad Aly RifaiDelmar D Short
May 17, 2006·Annals of Internal Medicine·Anne C SpauldingJay H Hoofnagle
Aug 26, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kathleen E CoreyRaymond T Chung
Feb 6, 2007·Drug and Alcohol Dependence·Jennifer V CampbellUNKNOWN DUIT Study Team
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair YounossiJohn Kincaid
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Savino BrunoUNKNOWN Italian Association of the Study of the Liver Disease (AISF)
Mar 16, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Lennox J Jeffers
May 16, 2007·Infectious Disease Clinics of North America·R Douglas Bruce, Frederick L Altice
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mitchell L ShiffmanArun J Sanyal
Aug 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Martin SchaeferThomas Berg
Sep 15, 2007·The International Journal on Drug Policy·Diana L Sylvestre, Joan E Zweben

❮ Previous
Next ❯

Citations

Jan 31, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrew R LloydDenise Monkley
Mar 20, 2009·Journal of Clinical Gastroenterology·Kara W ChewEdward Feller
Jul 3, 2010·Journal of Gastroenterology and Hepatology·John P BateHugh A J Harley
Jul 3, 2010·Journal of Gastroenterology and Hepatology·Lisa Ferguson, Robert Batey
Aug 16, 2013·BMC Infectious Diseases·Fabio IacomiFabrizio Palmieri
Dec 17, 2009·American Journal of Public Health·C Kent MartinJohn J Hagan
Aug 2, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey J PostAndrew R Lloyd
May 3, 2014·Gastroenterología y hepatología·Pablo Saiz de la HoyaEdelmira Pozo
Nov 14, 2014·American Journal of Public Health·Curt G BeckwithIrene Kuo
Jan 22, 2010·Journal of Women's Health·Sandra A Springer
Mar 5, 2015·Journal of Public Health·Curt G BeckwithIrene Kuo
Apr 17, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John P RiceMichael R Lucey
Dec 5, 2014·The Lancet. HIV·Jaimie P MeyerFrederick L Altice
Aug 15, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S L ScholzD Meller
Apr 2, 2015·Journal of Urban Health : Bulletin of the New York Academy of Medicine·John T NguyenBrian T Montague
Mar 5, 2016·International Journal of Prisoner Health·Michael Mokhlis MinaAndrew Lloyd
May 19, 2018·Current HIV/AIDS Reports·Katherine M RichJudith Feinberg
Jun 1, 2018·Journal of Viral Hepatitis·A MarcoUNKNOWN In and Out of Prison Study Group
Feb 26, 2009·The American Journal of Gastroenterology·Douglas R Hunt, Sammy Saab
Nov 10, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gerald Friedland
Jul 26, 2019·Current Opinion in HIV and AIDS·Adeeba KamarulzamanFrederick L Altice
Sep 29, 2015·World Journal of Hepatology·Rosa ZampinoEvangelista Sagnelli
Jul 23, 2012·Clinical Liver Disease·John RiceMichael R Lucey

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