Clinical outcomes of kidney transplantation in older end-stage renal disease patients: A nationwide cohort study

Geriatrics & Gerontology International
Eun Jeong KoKorean Organ Transplantation Registry Study Group

Abstract

The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients. We compared the incidence of biopsy-proven acute rejection, death-censored allograft survival and all-cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients. A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age >60 years (n = 356), and recipients aged <60 years were defined as young recipients (n = 4610). The incidence of biopsy-proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death-censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living d...Continue Reading

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Citations

Oct 3, 2019·Current Opinion in Nephrology and Hypertension·Lavanya Kodali, Alexandra Turner
Aug 18, 2020·Journal of Renal Care·Yu Hsuan ChangShiow Ching Shun
Mar 1, 2021·The American Journal of the Medical Sciences·Maria Aurora Posadas SalasDavid Taber
Jul 9, 2021·Kidney Research and Clinical Practice·Yohan ParkChul Woo Yang

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