Clinical Outcomes of Patients With Recurrent Lung Cancer Reirradiated With Proton Therapy on the Proton Collaborative Group and University of Florida Proton Therapy Institute Prospective Registry Studies

Practical Radiation Oncology
Shahed N BadiyanCharles B Simone

Abstract

We sought to assess clinical outcomes and toxicities of patients with recurrent lung cancer reirradiated with proton beam therapy (PBT) who were enrolled in 2 prospective registry trials. Seventy-nine consecutive patients were reirradiated with PBT at 8 institutions. Conventionally fractionated radiation therapy was used to treat the previous lung cancer in 68% of patients (median equivalent dose in 2 Gy fractions [EQD2], 60.2 Gy) and hypofractionated/stereotactic body radiation therapy in 32% (median EQD2, 83.3 Gy). Nine patients (11%) received ≥2 courses of thoracic irradiation before PBT. Eastern Cooperative Oncology Group (ECOG) performance status was 2 to 3 in 13%. Median time from prior radiation therapy to PBT was 19.9 months. PBT was delivered with conventional fractionation in 58% (median EQD2, 60 Gy), hyperfractionation in 3% (median EQD2, 62.7 Gy), and hypofractionation in 39% (median EQD2, 60.4 Gy). Twenty-four patients (30%) received chemotherapy concurrently with PBT. All patients completed PBT as planned. At a median follow-up of 10.7 months after PBT, median overall survival (OS) and progression-free survival (PFS) were 15.2 months and 10.5 months, respectively. Acute and late grade 3 toxicities occurred in 6% a...Continue Reading

Citations

Dec 6, 2019·The British Journal of Radiology·Esther G C TroostDirk de Ruysscher
Apr 24, 2020·Expert Review of Anticancer Therapy·Niccolò Giaj-LevraFilippo Alongi
Oct 30, 2020·Expert Review of Anticancer Therapy·Nirav V PatelPranshu Mohindra
Mar 8, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Cristina M DeCesarisJason K Molitoris
Feb 22, 2021·Seminars in Radiation Oncology·Benjamin HunterAhmed Salem
Apr 2, 2021·Radiation Oncology Journal·Hyunju ShinDongryul Oh
May 8, 2021·World Journal of Clinical Oncology·Mikel RicoFelipe Couñago
May 29, 2021·International Journal of Radiation Oncology, Biology, Physics·Robert W MutterShannon M MacDonald
Jul 22, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J DoyenP Y Bondiau

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