Abstract
Simultaneous second primary tumors (SSPT) are not uncommon in patients with oral cavity squamous cell carcinoma (OSCC) living in areas where the habit of betel quid chewing is widespread. We sought to identify the main prognostic factors in OSCC patients with SSPT and incorporate them into a risk stratification scheme. A total of 1822 consecutive patients with primary OSCC treated between January 1996 and February 2014 were analyzed for the presence of SSPT. The 18-month and 5-year overall survival (OS) rates served as the main outcome measures. Of the 1822 patients, 77 (4%) were found to have SSPT (i.e, two malignancies identified within one month of each other). The 18-month and 5-year OS rates in patients without SSPT and with SSPT were 82% and 69%, and 72% and 53%, respectively (p = 0.0063). Patients with SSPT were further divided into patients with either esophageal cancer or hepatocellular carcinoma (eso-HCC subgroup, n = 8) and other tumors (NO eso-HCC subgroup, n = 69). After multivariate analysis, neck nodal extracapsular spread (ECS, n = 18) and the presence of eso-HCC were identified as independent adverse prognostic factors. The 18-month OS rates of SSPT patients with both eso-HCC and ECS (n = 5) vs. the remaining p...Continue Reading
References
Oct 21, 1999·Cancer Letters·K FukuzawaA Tsuburaya
Sep 24, 2004·Cancer·Hung-Ming WangNgan-Ming Tsang
Dec 19, 2006·Oral Oncology·Chun-Ta LiaoTzu-Chen Yen
Dec 23, 2008·International Journal of Radiation Oncology, Biology, Physics·Chun-Ta LiaoTzu-Chen Yen
May 4, 2010·International Journal of Radiation Oncology, Biology, Physics·Chien-Yu LinJoseph Tung-Chieh Chang
Jul 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Kang-Hsing FanJoseph Tung-Chieh Chang
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Chun-Ta LiaoTzu-Chen Yen
Oct 16, 2012·Oral Oncology·Chun-Ta LiaoTzu-Chen Yen
Jan 30, 2013·Annals of Surgical Oncology·Masaru MoritaYoshihiko Maehara
Mar 14, 2013·Head & Neck·Shuo-Hsiu HsuShih-An Liu
May 13, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Mohammed QaisiRobert Ord
Aug 30, 2014·Gut and Liver·Hyun LimJin Ho Kim
Oct 8, 2014·European Annals of Otorhinolaryngology, Head and Neck Diseases·P BouteD Chevalier
Citations
May 10, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tuan-Jen FangHui-Chen Chiang
Feb 2, 2019·Clinical and Experimental Otorhinolaryngology·Young-Hoon JooPhil-Sang Chung
Nov 8, 2018·Clinical Hemorheology and Microcirculation·Philipp KauffmannThiha Aung
Aug 5, 2020·Ear, Nose, & Throat Journal·Min-Su KimSoon Young Kwon
Jun 4, 2020·Oral Diseases·Jun YangMing Hu
Feb 21, 2021·Medicine·Deqiang PanGuang Zhu