Clinical outcomes of perioptic tumors treated with hypofractionated stereotactic radiotherapy using CyberKnife® stereotactic radiosurgery

Journal of Neuro-oncology
Putipun PuataweepongPornpan Yongvithisatid

Abstract

Stereotactic radiation technique is widely reported as an effective treatment for various types of benign intracranial tumors. However, single fraction radiosurgery (SRS) is not recommended for tumors located close to the optic apparatus due to the restricted radiation tolerance dose of the optic pathway. Recent advances in radiotherapy include advanced frameless radiosurgery using hypofractionated stereotactic radiotherapy (HSRT), and this has become an attractive treatment option for perioptic tumors within 2-3 mm of the optic pathway. Accordingly, the aim of this study was to investigate the clinical outcomes of perioptic tumors treated with HSRT using CyberKnife® (CK) robotic radiosurgery system relative to tumor control, vision preservation and toxicity. This retrospective analysis of prospectively collected data included consecutive 100 patients that were diagnosed with and treated for perioptic tumor at the Radiosurgery center, Ramathibodi Hospital during the January 2009 to December 2012 study period. The median tumor volume was 6.81 cm3 (range 0.37-51.6), and the median prescribed dose was 25 Gy (range 20-35) in 5 fractions (range 3-5). After the median follow-up time of 37.5 months (range 21-103), two patients develop...Continue Reading

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Citations

Feb 13, 2020·Medical Physics·James L BedfordUwe Oelfke
Aug 9, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Tugce ApaydinPinar Kadioglu
Jul 2, 2020·Journal of Neuro-oncology·Hyuk-Jin OhKyoungJun Yoon
Jan 1, 2019·World Journal of Methodology·Tomaz Velnar, Roman Bosnjak
Mar 11, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Timo DeutschbeinMartin Fassnacht
Mar 25, 2019·World Neurosurgery·Aaron R PlittSamuel L Barnett

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