Clinical parameters predicting failure of empirical antibacterial therapy in early onset neonatal sepsis, identified by classification and regression tree analysis.

BMC Pediatrics
Tuuli MetsvahtIrja Lutsar

Abstract

About 10-20% of neonates with suspected or proven early onset sepsis (EOS) fail on the empiric antibiotic regimen of ampicillin or penicillin and gentamicin. We aimed to identify clinical and laboratory markers associated with empiric antibiotic treatment failure in neonates with suspected EOS. Maternal and early neonatal characteristics predicting failure of empiric antibiotic treatment were identified by univariate logistic regression analysis from a prospective database of 283 neonates admitted to neonatal intensive care unit within 72 hours of life and requiring antibiotic therapy with penicillin or ampicillin and gentamicin. Variables, identified as significant by univariate analysis, were entered into stepwise multiple logistic regression (MLR) analysis and classification and regression tree (CRT) analysis to develop a decision algorithm for clinical application. In order to ensure the earliest possible timing separate analysis for 24 and 72 hours of age was performed. At 24 hours of age neonates with hypoglycaemia < or = 2.55 mmol/L together with CRP values > 1.35 mg/L or those with BW < or = 678 g had more than 30% likelihood of treatment failure. In normoglycaemic neonates with higher BW the best predictors of treatmen...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G ReibneggerH Wachter
Mar 1, 1995·Clinical Pediatrics·R HeimlerP Sasidharan
Jan 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·A Mehta
Aug 1, 1996·The Journal of Pediatrics·R L SchelonkaD P Ascher
Apr 1, 1997·The Pediatric Infectious Disease Journal·J A KelloggD A Bankert
Apr 18, 2000·Lancet·P de ManJ N van den Anker
Jun 2, 2000·Journal of Clinical Microbiology·J A KelloggD A Bankert
Dec 4, 2002·American Journal of Infection Control·Naomi P O'gradyUNKNOWN Healthcare Infection Control Practices Advisory Committee
Aug 17, 2004·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Shiliang LiuUNKNOWN Maternal Health Study Group of the Canadian Perinatal Surveillance System
Oct 21, 2004·The Cochrane Database of Systematic Reviews·E I Mtitimila, R W I Cooke
Aug 12, 2005·Acta Paediatrica·José B López SastreUNKNOWN Grupo de Hospitales Castrillo
Apr 25, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·U K MishraS M Garland
Jul 25, 2006·Critical Care : the Official Journal of the Critical Care Forum·Jose Garnacho-MonteroCarlos Ortiz-Leyba
Nov 14, 2006·Journal of Paediatrics and Child Health·Luke JardineJoan Faoagali
Nov 24, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R P H PetersA B J Groeneveld
May 15, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Elsa Kermorvant-DucheminOlivier Claris

❮ Previous
Next ❯

Citations

Nov 27, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·A R Bedford Russell, R Kumar
Sep 1, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohamed Sami El ShimiNahed Samy Shedeed
Oct 13, 2020·Journal of Veterinary Internal Medicine·Martin Furr, Harold McKenzie

❮ Previous
Next ❯

Software Mentioned

R
package R

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Renato LucchiniMario De Curtis
The Pediatric Infectious Disease Journal
Michael Cohen-WolkowiezP Brian Smith
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Khalid N Haque
BMJ : British Medical Journal
Anthony D SoOtto Cars
© 2022 Meta ULC. All rights reserved