Clinical parameters that predict histology of postchemotherapy retroperitoneal lymph node mass in testicular cancer

International Journal of Urology : Official Journal of the Japanese Urological Association
Mizuki OnozawaHideyuki Akaza

Abstract

Since the advent of cisplatin-based chemotherapy, the majority of metastatic testicular cancers can be cured by chemotherapy followed by retroperitoneal lymph node dissection (RPLND). However, postchemotherapy RPLND confers no therapeutic benefit if the residual mass contains no viable cells. Therefore, to determine which parameters predict a patient's likelihood of having only necrosis in the residual mass, we retrospectively analyzed clinical parameters of patients who underwent postchemotherapy RPLND. Data from 27 patients with metastatic testicular cancer were analyzed. The histology of the primary tumor was seminoma in 11 cases and non-seminoma in 16 cases. All of the patients with non-seminoma showed a normalization of tumor markers after chemotherapy. Analysis of clinical parameters included data for the initial histology, pretreatment tumor marker levels, postchemotherapy retroperitoneal mass size, and the histology of the dissected RPLNs. Histological examination of dissected RPLNs showed residual tumor in 27% of seminoma patients and 38% of non-seminoma patients. In seminoma patients, no viable cells were found in all six patients with pretreatment lactate dehydrogenase (LDH) levels below 7.5 times the upper limit of ...Continue Reading

References

Apr 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S D FossåK E Giercksky
Jun 1, 1992·American Journal of Obstetrics and Gynecology·R AlmogC Samsonoff
Oct 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E L FriedmanJ P Richie
Jun 4, 1987·The New England Journal of Medicine·S D WilliamsP J Loehrer
Oct 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M SchultzP J Loehrer
Jan 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J MencelG J Bosl
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E W SteyerbergJ P Donohue
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J DebonoJ P Donohue
Jul 24, 1997·The New England Journal of Medicine·G J Bosl, R J Motzer
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E W SteyerbergH J Keizer
Jul 26, 2000·International Journal of Urology : Official Journal of the Japanese Urological Association·J MiyazakiH Akaza
May 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MazumdarG J Bosl
Sep 5, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M De SantisJ Pont

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.