Clinical parameters to predict response to interferon in relapsing multiple sclerosis

Neuroepidemiology
A FromontT Moreau

Abstract

To identify clinical parameters of response to beta-interferon (IFN-beta) in relapsing-remitting multiple sclerosis (RRMS) from an East France cohort. Data from 2,645 patients, identified by Burgundy and Lorraine multiple sclerosis (MS) networks, were computerized by a neurologist using the European Database for MS software. Patient inclusion criteria were: clinically or laboratory-supported definite RRMS according to Poser's diagnostic criteria and treatment with IFN-beta for at least 6 months. Four criteria were chosen to predict a response to IFN-beta. The first criterion was any patient who had a lower annualized relapse rate under IFN-beta therapy than during the year preceding treatment; the second criterion was a lower relapse rate than during the 2 years preceding treatment. The third was any patient free of relapse during the first 2 years of IFN-beta therapy. The last criterion concerned the variation in the degree of disability measured by the Disability Status Scale during the first year of treatment. Multivariate logistic regression analyses were performed. 751 RRMS cases were included. A higher relapse rate in the year preceding IFN-beta onset, an older age at MS onset and having a polysymptomatic onset of MS were...Continue Reading

Citations

Jul 31, 2013·Nature Reviews. Neurology·Maria Pia Sormani, Nicola De Stefano
Mar 19, 2014·The International Journal of Neuroscience·Nicolò MargaritellaLuigi Pugnetti
Feb 22, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M RomeoUNKNOWN San Raffaele Multiple Sclerosis Clinical Group
Apr 8, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M RomeoUNKNOWN San Raffaele Multiple Sclerosis Clinical Group
Oct 21, 2017·Brain : a Journal of Neurology·Tomas KalincikUNKNOWN MSBase Study Group
Feb 25, 2021·Annals of Clinical and Translational Neurology·Yuri AhujaZongqi Xia

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