PMID: 2482638Jan 1, 1989Paper

[Clinical pathology of the glomerulus--from phenomenon to entity. The extracapillary lesion].

Verhandlungen der Deutschen Gesellschaft für Pathologie
H J Rumpelt

Abstract

Glomerular crescents are accumulations of proliferating cells in Bowman's capsule and develop as a consequence of glomerular capillary wall ruptures. The severity of crescentic lesion (% glomeruli affected) and crescent size (segmental vs global) are correlated: the higher the percentage of crescentic glomeruli, the more of them are global ones. Several age stages can be differentiated: cellular, fibrocellular, and fibrous crescents. Cellular crescents are mainly composed of epithelial cells derived from the visceral and parietal epithelium, while macrophages and granulocytes are intermingled in widely varying numbers. Crescents can appear in most forms of glomerulonephritis (gn). High percentages of crescents (more than 50%) may be associated 1. with glomerulonephritides of other definition (especially postinfectious gn, mesangial-proliferative gn, IgA-nephritis, membranoproliferative gn, LE-nephritis, Schönlein-Henoch nephritis, cryoglobulinemia) and 2. are the substantial alteration in intra-extracapillary proliferative gn (IEKPGN). Among the latter three forms can be distinguished. a) Anti-glomerular-basement membrane-nephritis and Goodpasture syndrome, respectively (28% of cases), M. Wegener and other vasculitides (8%), an...Continue Reading

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