Clinical pattern characterization of cattle naturally infected by BTV-8

Transboundary and Emerging Diseases
G ZanellaClaude Saegerman

Abstract

Forty-one cattle from seven Belgian farms and two French farms confirmed as infected with bluetongue virus serotype 8 (BTV-8) were monitored from the onset of clinical signs to describe the disease pattern and estimate the duration of blood RT-qPCR and competitiveELISA positivity under field conditions. On each visit, blood samples were taken, and a standardized clinical form was filled in for each animal. A clinical score was calculated for every week until the end of clinical signs. A classification and regression tree (CART) analysis was conducted to determine the most important clinical signs every week for the first 7 weeks. The highest scores were recorded within 2 weeks of clinical onset. The first recorded clinical signs were quite obviously visible (lethargy, conjunctivitis, lesions of nasal mucosa, nasal discharge). Skin lesions, a drop in milk production and weight loss appeared later in the course of the disease. A biphasic pattern regarding nasal lesions was noticed: the first peak concerned mainly congestive and ulcerative lesions, whereas the second peak mainly concerned crusty lesions. The median time estimated by survival analysis to obtain negative RT-qPCR results from the onset of clinical signs was 195 days ...Continue Reading

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Citations

Jun 19, 2015·Vector Borne and Zoonotic Diseases·D Scott McVey, N James MacLachlan
Apr 1, 2018·Transboundary and Emerging Diseases·C DaudtC W Canal
Nov 6, 2018·Transboundary and Emerging Diseases·Emmanuel BréardDamien Vitour
Dec 29, 2019·Transboundary and Emerging Diseases·C VinomackG Zanella
Jul 18, 2017·PloS One·Dennis vanEngelsdorpDiana L Cox-Foster
Sep 25, 2017·Transboundary and Emerging Diseases·N CourtejoieG Zanella
Mar 27, 2020·Frontiers in Veterinary Science·Anouk M B VeldhuisGerdien van Schaik
Mar 12, 2021·PloS One·Claude SaegermanAlexandre Ghuysen

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