Clinical patterns and treatment outcome of elderly patients in clinical stage IB/II non-small cell lung cancer

Journal of Surgical Oncology
Tatsuro OkamotoYukito Ichinose

Abstract

Surgery is a standard treatment in patients with clinical stage IB/II non-small cell lung cancer (NSCLC). We often have difficulty in treating of elderly patients due to their insufficient physiological function. To better manage such elderly patients, the clinical characteristics and prognosis of patients with these stages, who were 75 years of age or older, were reviewed. From 1972 to 1999, 112 elderly patients with these stages were treated in our department. These patients comprised 88 men and 24 women. The histological types were 50 adenocarcinomas, 51 squamous cell carcinomas, 8 large cell carcinomas, and 3 adenosquamous carcinomas. Seventy-four patients (66%) underwent a surgical resection, including 60 surgery alone, 14 combined modality therapy. Radiotherapy, with or without chemotherapy, was given to 30 patients (27%), and chemotherapy alone to 5 (4.5%). In addition, 3 (2.7%) were given no therapy. The survivals of the surgery group at 2 and 5 years are 53% and 21% and those of the radiotherapy group are 35% and 3%, respectively. A multivariate analysis in radiotherapy group shows the predominant prognostic factor to be adenocarcinoma. The 2-year survival of the radiotherapy group in patients with adenocarcinoma is 58...Continue Reading

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Citations

Feb 3, 2007·Current Opinion in Oncology·Lorenzo Spaggiari, Paolo Scanagatta
Sep 20, 2005·Critical Reviews in Oncology/hematology·Fausto Meriggi, Alberto Zaniboni
Oct 4, 2018·Journal of Medical Imaging and Radiation Oncology·Andrew D NguyenShalini K Vinod
Mar 7, 2017·Turkish Journal of Medical Sciences·İlknur AytekinLevent Elbeyli

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