Clinical performance and radiation dosimetry of no-carrier-added vs carrier-added 123I-metaiodobenzylguanidine (MIBG) for the assessment of cardiac sympathetic nerve activity

European Journal of Nuclear Medicine and Molecular Imaging
Hein J VerberneBerthe L F van Eck-Smit

Abstract

We hypothesized that assessment of myocardial sympathetic activity with no-carrier-added (nca) (123)I-meta-iodobenzylguanidine (MIBG) compared to carrier-added (ca) (123)I-MIBG would lead to an improvement of clinical performance without major differences in radiation dosimetry. In nine healthy volunteers, 15 min and 4 h planar thoracic scintigrams and conjugate whole-body scans were performed up to 48 h following intravenous injection of 185 MBq (123)I-MIBG. The subjects were given both nca and ca (123)I-MIBG. Early heart/mediastinal ratios (H/M), late H/M ratios and myocardial washout were calculated. The fraction of administered activity in ten source organs was quantified from the attenuation-corrected geometric mean counts in conjugate views. Radiation-absorbed doses were estimated with OLINDA/EXM software. Both early and late H/M were higher for nca (123)I-MIBG (ca (123)I-MIBG early H/M 2.46 +/- 0.15 vs nca (123)I-MIBG 2.84 +/- 0.15, p = 0.001 and ca (123)I-MIBG late H/M 2.69 +/- 0.14 vs nca (123)I-MIBG 3.34 +/- 0.18, p = 0.002). Myocardial washout showed a longer retention time for nca (123)I-MIBG (p < 0.001). The effective dose equivalent (adult male model) for nca (123)I-MIBG was similar to that for ca (123)I-MIBG (0.0...Continue Reading

References

Jan 1, 1970·Histochemie. Histochemistry. Histochimie·J B Furness
Jan 1, 1995·Nuclear Medicine and Biology·T R DegradoG Vaidyanathan
Jan 1, 1995·Nuclear Medicine and Biology·G Vaidyanathan, M R Zalutsky
Apr 25, 2000·European Journal of Nuclear Medicine·M KnickmeierM Schäfers
Oct 24, 2001·Health Physics·L K NgutterR J Vetter
Mar 31, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G Aernout SomsenAlberto Righetti
May 20, 2005·European Heart Journal·Karl SwedbergUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology
May 20, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Hein J VerberneEllinor Busemann Sokole
Sep 20, 2005·Journal of the American College of Cardiology·Sharon Ann HuntUNKNOWN American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evalua
Jan 21, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Hein J VerberneBerthe L F van Eck-Smit

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Citations

Jun 6, 2012·International Journal of Molecular Imaging·Derk O VerschureHein J Verberne
Mar 12, 2010·Nuclear Medicine Communications·Linda van der VeenMarcel Stokkel
Mar 15, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bennett B ChinJohn W Babich

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OLINDA
SPSS
EXM

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