Clinical performance of the 4Kscore Test to predict high-grade prostate cancer at biopsy: A meta-analysis of us and European clinical validation study results

Reviews in Urology
Stephen ZappalaYan Dong

Abstract

The 4Kscore® Test (OPKO Diagnostics, Woburn, MA) is a blood test utilized prior to a prostate biopsy to determine a patient's risk of high-grade prostate cancer (PCa) should the biopsy be performed, thus providing critical information in the clinical management of men with a suspicious prostate-specific antigen value or digital rectal examination result. Multiple US and European clinical studies confirmed that a prebiopsy 4Kscore Test has a high degree of discrimination for a subsequent discovery of high-grade (Gleason score ≥7) PCa. The aim of this study was to evaluate the predictive accuracy of the 4Kscore Test to discriminate between patients with and without high-grade PCa based on published clinical validation studies. A systematic review and meta-analysis of the eligible 4Kscore Test clinical validation studies was conducted. The pooled area under the curve (AUC) of the 4Kscore Test as reported from all the studies, and the heterogeneity among these studies were analyzed and repeated for subgroups of the studies. Twelve clinical validation studies were included in the meta-analysis, comprising a total of 11,134 patients. The pooled AUC to discriminate for high-grade PCa for all 12 studies was 0.81 (fixed effects 95% CI, ...Continue Reading

Citations

Jun 18, 2020·Cancers·Felipe CouñagoElia Del Cerro
Sep 12, 2018·Diagnostics·Arlou Kristina AngelesHolger Sültmann
Sep 10, 2020·Postgraduate Medicine·William W French, Eric M Wallen
May 25, 2021·Frontiers in Oncology·Sophia C Kamran, Jason A Efstathiou
Jul 21, 2021·Cancers·Milena MatuszczakMaciej Salagierski

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