Clinical perspective - cough: an unmet need

Current Opinion in Pharmacology
Peter V Dicpinigaitis

Abstract

Cough is among the most common complaints for which individuals worldwide seek medical attention. The vast majority of cases of acute cough (<3 weeks duration) are due to acute viral upper respiratory tract infection (URI) (common cold). Fortunately, acute cough is typically transient and self-limited. However, should severe and/or persistent acute cough require pharmacological treatment, satisfactory therapeutic options are scarce. Narcotic antitussives are limited by unacceptable side effects at therapeutic doses, and most over-the-counter (OTC) remedies are not supported by adequate clinical trials. The goal in chronic cough (>8 weeks duration) is to meticulously evaluate and treat all potential underlying etiologies. Despite thorough investigation, a significant minority of patients will suffer refractory, unexplained cough. For this challenging population, safe, effective, non-narcotic antitussive therapies are desperately needed.

References

Jun 1, 1992·Journal of Clinical Pharmacy and Therapeutics·R EcclesM Jawad
Nov 19, 1997·The Journal of Pharmacy and Pharmacology·C Freestone, R Eccles
Jan 24, 2006·Chest·Richard S IrwinUNKNOWN American College of Chest Physicians (ACCP)
Dec 30, 2008·Pulmonary Pharmacology & Therapeutics·Milos TatarMarian Kollarik
Mar 7, 2009·The New England Journal of Medicine·Pranabashis HaldarIan D Pavord
Dec 22, 2009·Lung·Jaclyn SmithLesley Houghton
Jul 6, 2010·Gastroenterology·Jaclyn A SmithLesley A Houghton
Jul 10, 2012·Pulmonary Pharmacology & Therapeutics·Francesco De BlasioAlessando Zanasi
Dec 18, 2013·Lung·Akio NiimiPeter V Dicpinigaitis
Jan 28, 2014·The Lancet. Respiratory Medicine·Kay WangAnthony Harnden
Feb 15, 2014·World Journal of Cardiology·Adel AminianDariouch Dolatabadi
Feb 15, 2014·World Journal of Clinical Cases·Elena LionettiMario La Rosa
Mar 29, 2014·Pharmacological Reviews·P V DicpinigaitisC P Page
Aug 22, 2014·The European Respiratory Journal·Alyn H MoriceJaclyn A Smith

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Citations

Jan 8, 2016·Trends in Endocrinology and Metabolism : TEM·Silke Otter, Eckhard Lammert
Jul 17, 2015·Clinical and Translational Allergy·Woo-Jung Song, Yoon-Seok Chang
Jun 16, 2016·American Journal of Respiratory and Critical Care Medicine·Stuart B Mazzone
Feb 19, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Concepción PazAdrián Cabarcos
Aug 8, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Concepción PazJesús Vence
Apr 18, 2020·Expert Opinion on Pharmacotherapy·Woo-Jung Song, Kian Fan Chung
Mar 5, 2016·Journal of Applied Physiology·Nastasia V WasilewskiM Diane Lougheed
Mar 24, 2017·Journal of Analytical Toxicology·Sandra C Bishop-FreemanRuth E Winecker
Jan 17, 2017·Cell and Tissue Research·Katrin Julia AudritChristina Nassenstein
Jan 13, 2017·Turkish Journal of Medical Sciences·Guiyuan JiangDongping Xu
Mar 24, 2017·Scientific Reports·Meng-Meng XiaoJing-Yan Han

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