PMID: 8582893Jan 1, 1995Paper

Clinical perspectives of platelet transfusions: defining the optimal dose

Journal of Clinical Apheresis
R G Strauss

Abstract

To halt bleeding in patients with severe thrombocytopenia due to bone marrow failure, it is desirable to achieve a post-transfusion blood platelet count of 40 x 10(9)/L by platelet transfusions. Based on calculations of corrected count increments, each 1 x 10(11) platelets transfused will increase the blood platelet count approximately 10 x 10(9)/L per each square meter of patient body surface area. Thus, the post-transfusion blood platelet count will be approximately 20 x 10(9)/L following transfusion of 3 x 10(11) platelets to a 5 foot, 8 inch patient weighing 170 pounds (2.0 m2), who is bleeding because of a pre-transfusion platelet count of 5 x 10(9)/L. The post-transfusion platelet count likely will be even lower in sick patients (sepsis, amphotericin B plus antibiotic therapy, splenomegaly, graft-vs.-host disease, etc.) or if platelets are lost from the unit by leukofiltration before transfusion. Although a dose of 3 x 10(11) platelets is acceptable, in a regulatory sense for product quality, it is inadequate to control bleeding in most thrombocytopenic adult patients. Adjusting dose for body size, bleeding patients with pre-transfusion blood platelet of < 10 x 10(9)/L and weighing > 120 pounds should receive approximatel...Continue Reading

References

Aug 1, 1990·Seminars in Oncology Nursing·T Chamorro
Jan 1, 1994·Vox Sanguinis·V S GharpureC A Schiffer
Jan 1, 1995·Journal of Clinical Apheresis·F B Axelrod, P W Ooley

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Citations

Sep 27, 2003·Indian Journal of Pediatrics·K M RadhakrishnanJ Jayaraju
Dec 20, 1999·Transfusion Medicine Reviews·L A Chambers, J H Herman
Feb 7, 2001·Gastroenterology Clinics of North America·G S MaltzJ L Carson
May 3, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Howard R Schlossberg, Jay H Herman
Aug 15, 1998·Vox Sanguinis·S Hiippala
Mar 13, 2003·Journal of Vascular and Interventional Radiology : JVIR·Michael J WallaceMarshall E Hicks
Sep 5, 2002·Journal of Clinical Apheresis·Sabeen AskariJohn Crosson
Oct 12, 2005·Current Opinion in Hematology·Ronald G Strauss
Sep 27, 2005·Transfusion·Thomas FearonNaomi L C Luban
Oct 30, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ozlem Unay DemirelMustafa Cagatay Buyukuysal

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