Clinical perspectives of TRAIL: insights into central nervous system disorders

Cellular and Molecular Life Sciences : CMLS
Veronica TisatoGiorgio Zauli

Abstract

The TNF-related apoptosis inducing ligand TRAIL is a member of the TNF superfamily that has been firstly studied and evaluated for its anti-cancer activity, and the insights into its biology have already led to the identification of several TRAIL-based anticancer strategies with strong clinical therapeutic potentials. Nonetheless, the TRAIL system is far more complex and it can lead to a wider range of biological effects other than the ability of inducing apoptosis in cancer cells. By virtue of the different receptors and the different signalling pathways involved, TRAIL plays indeed a role in the regulation of different processes of the innate and adaptive immune system and this feature makes it an intriguing molecule under consideration in the development/progression/treatment of several immunological disorders. In this context, central nervous system represents a peculiar anatomic site where, despite its "status" of immune-privileged site, both innate and adaptive inflammatory responses occur and are involved in several pathological conditions. A number of studies have evaluated the role of TRAIL and of TRAIL-related pathways as pro-inflammatory or protective stimuli, depending on the specific pathological condition, confirm...Continue Reading

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Citations

Oct 1, 2016·The International Journal of Biochemistry & Cell Biology·Rebecca VoltanVeronica Tisato
Oct 27, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·William M Pardridge
Jul 19, 2019·Medical Microbiology and Immunology·Asadollah MohammadiHoushang Rafatpanah
Aug 14, 2019·Health Informatics Journal·Claus BossenEnrico Maria Piras
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May 18, 2019·Clinical Science·Stella BernardiVeronica Tisato
May 2, 2017·Mediators of Inflammation·Giorgio ZauliMauro Vaccarezza
Apr 4, 2021·International Journal of Molecular Sciences·Liya QinLeon G Coleman
Jul 16, 2021·Translational Vision Science & Technology·Louise A Mesentier-LouroYaping Joyce Liao

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Methods Mentioned

BETA
transgenic

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