Clinical perspectives on xenobiotic-induced hepatotoxicity

Drug Metabolism Reviews
Basuki Gunawan, Neil Kaplowitz

Abstract

Drug-induced hepatotoxicity is an important cause of liver disease with significant medical, economic, legal, and regulatory implications. Clinically, it presents a diagnostic challenge to health care professionals since drug-induced liver disease can mimic the clinicopathologic features of all other acute and chronic liver diseases. However, individual drugs tend to have a characteristic clinical signature. Early identification of hepatotoxicity by either laboratory monitoring or patients' awareness as a result of education may avert serious liver injury in delayed idiosyncratic toxicity. Most adverse hepatic reactions require metabolism of the drug to reactive metabolites and free radicals, which then either lead to direct overwhelming lethal insult, nonlethal sensitization to the lethal effects of the innate immune system, or haptenization eliciting an immunoallergic response of the adaptive immune system. Besides licensed drugs, herbal and natural supplements are recognized as causing hepatotoxicity with increasing frequency as patients turn more and more to alternative medicine.

References

Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C DegottJ P Benhamou
Feb 1, 1994·Gastroenterology·J LoeperD Pessayre
Jan 1, 1997·Journal of Hepatology·V J Desmet
Mar 28, 1998·The New England Journal of Medicine·P B Watkins, R W Whitcomb
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M I LucenaF Sanchez De La Cuesta
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N Kaplowitz
Jul 11, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·N Kaplowitz
Mar 20, 2002·Annals of Internal Medicine·David W Nierenberg
Apr 17, 2002·Annals of Internal Medicine·Joya T FavreauTse-Ling Fong
Apr 17, 2002·Annals of Internal Medicine·James D Lewis, Brian L Strom
May 1, 2002·JAMA : the Journal of the American Medical Association·Karen E LasserDavid H Bor
May 23, 2002·Seminars in Liver Disease·Neil Kaplowitz
Oct 5, 2002·Clinics in Liver Disease·Zhang-Xu Liu, Neil Kaplowitz
Dec 18, 2002·Annals of Internal Medicine·George OstapowiczUNKNOWN U.S. Acute Liver Failure Study Group
Apr 12, 2003·The American Journal of Medicine·David J GrahamParivash Nourjah

❮ Previous
Next ❯

Citations

Feb 7, 2012·Expert Reviews in Molecular Medicine·Xinsheng Gu, Jose E Manautou
Apr 6, 2006·The AAPS Journal·Michael P Holt, Cynthia Ju
Sep 19, 2009·Pharmacogenomics·Raúl J AndradeM Isabel Lucena
Jun 18, 2009·World Journal of Gastroenterology : WJG·Giovanni TarantinoDomenico Capone
Aug 17, 2011·Indian Journal of Pharmacology·Inderpal Kaur, Jatinder Singh
Aug 23, 2006·Expert Opinion on Drug Metabolism & Toxicology·Amit S Kalgutkar, John R Soglia
Dec 9, 2009·Expert Opinion on Drug Safety·Raúl J AndradeMaría Isabel Lucena
Jan 13, 2012·Drug Metabolism Reviews·Cynthia Ju, Timothy Reilly
Nov 28, 2013·Emergency Medicine Clinics of North America·Annette M Lopez, Robert G Hendrickson
Dec 5, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hiroko HosomiTsuyoshi Yokoi
Aug 29, 2007·Clinics in Liver Disease·Basuki K Gunawan, Neil Kaplowitz
Nov 27, 2008·British Journal of Clinical Pharmacology·Rolf TeschkeKarl-Heinz Hennermann
Jul 19, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hajime Takikawa
Apr 18, 2008·Journal of Applied Toxicology : JAT·T J MillerJ P Hanig
Jan 29, 2013·Journal of Clinical Pharmacy and Therapeutics·M Sistanizad, G M Peterson
Aug 30, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Rolf TeschkeAxel Eickhoff
Dec 12, 2013·Journal of Gastroenterology and Hepatology·Shima HatamkhaniSirous Jafari
Apr 1, 2006·Drug Discovery Today. Technologies·Norberto A GuzmanTerry M Phillips
Feb 14, 2006·Analytical Biochemistry·Georgina Meneses-LorenteAlan P Watt
Jun 14, 2008·Journal of Hepatology·Louis IgnarroEzra Bejar
Mar 20, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Naomi Jessurun, Eugene van Puijenbroek
May 2, 2012·Allergy, Asthma & Immunology Research·Jae-Woo KwonUNKNOWN Adverse Drug Reaction Research Group in Korea
Sep 22, 2010·Regulatory Toxicology and Pharmacology : RTP·Rolf Teschke, Albrecht Wolff
Sep 7, 2011·Regulatory Toxicology and Pharmacology : RTP·Rolf TeschkeJohannes Schulze
Aug 9, 2012·Chemical Research in Toxicology·Mackenzie HadiGeny M M Groothuis
Jul 13, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amy Christine Brown
Sep 7, 2007·Digestive Diseases and Sciences·Wissam BleibelEric R Lemmer
Jul 5, 2007·The Annals of Pharmacotherapy·Kevin P DeSanty, Celene M Amabile
Jun 3, 2005·Nature Reviews. Drug Discovery·Neil Kaplowitz
Nov 8, 2008·European Journal of Gastroenterology & Hepatology·Rolf TeschkeKarl-Heinz Hennermann
Feb 11, 2005·Current Gastroenterology Reports·Robert G BateyAlan Bensoussan
Apr 2, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Sabrina CrepinMarie-Laure Laroche
Mar 28, 2019·Current Drug Metabolism·Mohammad K Parvez, Vikas Rishi
Apr 6, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gebran Abboud, Neil Kaplowitz
Nov 7, 2019·Current Pharmaceutical Design·Eva Rebelo GomesFrederico Regateiro
Apr 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin ZhangPin Li
Mar 20, 2021·Médecine sciences : M/S·Brendan Le DaréThomas Gicquel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Neil Kaplowitz
Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Neil Kaplowitz
© 2022 Meta ULC. All rights reserved