Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

Clinical Pharmacology and Therapeutics
Jacob T BrownJ Steven Leeder

Abstract

Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).

References

May 1, 1985·Journal of Clinical Pharmacology·N A FaridL Lemberger
Feb 21, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Barbara J RingSteven A Wrighton
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·John-Michael SauerKarl A Desante
Aug 23, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Christopher J KratochvilJoseph Biederman
Jan 24, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·David MichelsonJames McCracken
Jul 6, 2007·British Journal of Clinical Pharmacology·Yi M CuiStephen D Wise
Aug 19, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Paula T TrzepaczJan K Buitelaar
Nov 1, 2007·Clinical Pharmacology and Therapeutics·A GaedigkJ S Leeder
Jan 25, 2008·The International Journal of Neuropsychopharmacology·Michael PaulzenGerhard Gründer
Mar 26, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Jeffrey H NewcornCalvin R Sumner
Apr 24, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicolas RamozPhilip Gorwood
Dec 30, 2011·Clinical Pharmacology and Therapeutics·K R CrewsUNKNOWN Clinical Pharmacogenetics Implementation Consortium
Sep 21, 2012·Clinical Pharmacology and Therapeutics·M Whirl-CarrilloT E Klein
Jan 25, 2014·Clinical Pharmacology and Therapeutics·K R CrewsUNKNOWN Clinical Pharmacogenetics Implementation Consortium
May 15, 2015·Clinical Pharmacology and Therapeutics·J K HicksUNKNOWN Clinical Pharmacogenetics Implementation Consortium
Jun 20, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·Jose de Leon
Aug 10, 2015·Archives of Pharmacal Research·Ji-Yeong ByeonSeok-Yong Lee
Dec 15, 2015·Clinical Pharmacology and Therapeutics·J T BrownJ S Leeder
Feb 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edoardo SpinaJose de Leon
Apr 8, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jean C DinhJ Steven Leeder
Aug 16, 2016·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Ioana TodorCorina Briciu
Nov 1, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics
Jan 25, 2018·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Melissa L DanielsonStephen J Blumberg
Feb 1, 2018·Clinical Pharmacology and Therapeutics·Matthew P GoetzTeri E Klein
Mar 2, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Georgios SchoretsanitisChristoph Hiemke

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Citations

Jan 21, 2019·Pediatric Research·Kazeem A OshikoyaSara L Van Driest
Sep 24, 2019·Clinical Pharmacology and Therapeutics·Charity NofzigerAndrea Gaedigk
Feb 18, 2020·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Abdullah Al MarufChad A Bousman
Jul 30, 2020·Expert Opinion on Drug Metabolism & Toxicology·Cameron D Thomas, Julie A Johnson
Jul 10, 2019·Annual Review of Pharmacology and Toxicology·Laura B RamseySara L Van Driest
May 20, 2020·Pharmacogenomics and Personalized Medicine·Mirko ManchiaBernardo Carpiniello
Mar 10, 2020·Archives of Pathology & Laboratory Medicine·Ann M MoyerKaren E Weck
Aug 10, 2019·Journal of Personalized Medicine·Catriona Hippman, Corey Nislow
Oct 13, 2020·Frontiers in Pharmacology·Ron H N van SchaikMagnus Ingelman-Sundberg
Oct 18, 2020·CPT: Pharmacometrics & Systems Pharmacology·Cameron D ThomasLarisa H Cavallari
Nov 5, 2020·Pharmacopsychiatry·Chad A BousmanDaniel J Müller
Nov 3, 2020·PLoS Computational Biology·Gregory McInnesErica L Woodahl
Dec 17, 2020·Clinical and Translational Science·Jacob T BrownSusan I Colace
Feb 4, 2021·Drug Development Research·Daniela FanniMirko Manchia
Dec 29, 2020·Frontiers in Genetics·Beatriz Carvalho HenriquesKatherine J Aitchison
Feb 12, 2021·Frontiers in Pharmacology·Heshu Abdullah-KoolmeesVera H M Deneer
Jan 12, 2021·Clinical Pharmacology and Therapeutics·J Kevin HicksUNKNOWN IGNITE Pharmacogenetics Working Group
Mar 30, 2021·Drug Metabolism and Personalized Therapy·Anna Yu IkonnikovaTatiana V Nasedkina
Apr 8, 2021·Pediatric Research·Sonya C Tang GirdwoodLaura B Ramsey
May 28, 2021·Clinical Pharmacology and Therapeutics·Daniel L HertzSara L Van Driest
Jun 30, 2021·Journal of Clinical Pharmacology·Keito HoshitsukiJun J Yang
Aug 9, 2021·Clinical Pharmacology and Therapeutics·Dyson T WakeHenry M Dunnenberger
Oct 8, 2021·Frontiers in Genetics·Shivashankar H Nagaraj, Maree Toombs
Aug 20, 2021·Pharmacogenetics and Genomics·Tyler ShuggJasmine A Luzum
Jan 28, 2022·Pharmacogenomics·Karen E BrownErica L Woodahl

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