Abstract
The pharmacokinetics and safety of ceforanide and cefazolin were compared in normal subjects after 30-min intravenous infusions of 2-, 3-, and 4-g single doses and 4-g twice-daily doses for 10 days. No significant differences were observed in plasma-renal pharmacokinetic parameters between single and multiple doses of ceforanide. Half-life (t((1/2)), 2.8 h), plasma clearance (Cl(p), 48 ml/min per 1.73 m(2)), and renal clearance (Cl(0-12h) (r), 47 ml/min per 1.73 m(2); tubular secretion, 44%, and glomerular filtration, 56%) did not change with increased dose or on multiple dosing. No significant change was observed in t((1/2)) (1.9 h), area under the plasma concentration-time curve, Cl(r) (60 ml/min per 1.73 m(2); tubular secretion, 80%, and glomerular filtration, 20%), or Cl(p) (75 ml/min per 1.73 m(2)) for 4-g single doses compared with twice-daily administration of cefazolin. A small increase in cefazolin clearance was observed when plasma concentrations were greater than 100 mug/ml, when the single dose was increased from 2 to 4 g; this was a result of the decrease in percentage of plasma protein binding and increased renal clearance due to increased glomerular filtration. The increase in renal clearance resulted in a lack o...Continue Reading
References
May 1, 1978·The Journal of Infectious Diseases·V T Andriole
Nov 1, 1977·The Journal of Antimicrobial Chemotherapy·E K BrodwallO Orjavik
May 1, 1978·The Journal of Infectious Diseases·M Barza
Jul 1, 1977·The Journal of Antibiotics·R N JonesE H Gerlach
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·F LeitnerK E Price
May 1, 1975·Urology·N BaumC E Carlton
Dec 1, 1975·Journal of Pharmaceutical Sciences·C H NightingaleR Quintiliani
Oct 1, 1973·The Journal of Infectious Diseases·H A BirkheadL Z Saunders
Jan 1, 1970·Journal of Pharmaceutical Sciences·J C Loo, S Riegelman
Jan 1, 1962·The American Journal of Medicine·P D DOOLANG B THEIL
Citations
Oct 19, 2011·Antimicrobial Agents and Chemotherapy·Mao HagiharaDavid P Nicolau
Oct 1, 1980·Antimicrobial Agents and Chemotherapy·J CarrizosaD Kaye
Feb 1, 1981·Antimicrobial Agents and Chemotherapy·R H CooperJ Mills
Apr 1, 1981·Antimicrobial Agents and Chemotherapy·F H LeeD R Van Harken
Feb 1, 1982·Antimicrobial Agents and Chemotherapy·A S DajaniR D Smyth
Feb 1, 1982·Antimicrobial Agents and Chemotherapy·S RipaM Pfeffer
May 1, 1983·Antimicrobial Agents and Chemotherapy·D E Kenady, M D Ram
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·J T DiPiroJ P Rissing
Sep 1, 1985·Antimicrobial Agents and Chemotherapy·J C Fleishaker, P J McNamara
Jan 1, 1986·Antimicrobial Agents and Chemotherapy·A L BarryR R Packer
Oct 1, 1986·Antimicrobial Agents and Chemotherapy·M N DudleyR Quintiliani
Jul 24, 2014·International Journal of Antimicrobial Agents·Seth T HousmanDavid P Nicolau
Mar 10, 2015·Bioanalysis·Susan HofmanJan-Willem C Alffenaar
Dec 18, 2019·Antimicrobial Agents and Chemotherapy·Warren E RoseSelvi C Ersoy
Jul 26, 2019·Journal of Clinical Microbiology·Iris H ChenJoseph L Kuti
Sep 20, 2019·Journal of Clinical Microbiology·Iris H ChenJoseph L Kuti
Nov 1, 1988·Drug Intelligence & Clinical Pharmacy·B H AckermanB H Harrison
Jul 1, 1985·Drug Intelligence & Clinical Pharmacy·P O Anderson
Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·T A Tartaglione, R E Polk
Sep 1, 1983·Drug Intelligence & Clinical Pharmacy·W J CadyW R Hamsa
Nov 1, 1982·Pharmacotherapy·S L Barriere, J Mills
Nov 4, 2020·Antimicrobial Agents and Chemotherapy·Maxwell J LaskoJoseph L Kuti
Jun 26, 2021·The AAPS Journal·Ke Xu SzetoViera Lukacova