Clinical pharmacokinetics of ethanol

Clinical Pharmacokinetics
N H Holford

Abstract

The pharmacokinetics of ethanol after typical doses are described by a 1-compartment model with concentration-dependent elimination. The volume of distribution estimated from blood concentrations is about 37 L/70 kg. Protein binding of ethanol has not been reported. Elimination is principally by metabolism in the liver with small amounts excreted in the breath (0.7%), urine (0.3%), and sweat (0.1%). Metabolism occurs, principally by alcohol dehydrogenase, in the liver to acetaldehyde. Models of ethanol input and absorption are crucial to the description and understanding of the effects of ethanol dose on bioavailability. Little attention has been paid to evaluation of potential models. First-pass extraction of ethanol is predicted to be dependent on hepatic blood flow and ethanol absorption rate, with a typical extraction ratio of 0.2. The overall elimination process can be described by a capacity-limited model similar to the Michaelis-Menten model for enzyme kinetics. The maximum rate of elimination of ethanol (elimination capacity or Vmax is 8.5 g/h/70 kg. This would be equivalent to a blood ethanol disappearance rate of 230 mg/L/h if metabolism took place at its maximum rate. The elimination rate is half of the elimination c...Continue Reading

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Citations

Aug 1, 1990·Journal of Clinical Pharmacology·F M GengoC Manning
Oct 22, 2008·European Journal of Clinical Pharmacology·Christian Queckenberg, Uwe Fuhr
Dec 23, 2004·Journal of Molecular Histology·George D Loizou, Martin Spendiff
Aug 1, 1995·Electroencephalography and Clinical Neurophysiology·D J O'BoyleK I Hume
May 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K ChhabraL M Anderson
Jan 18, 2006·Forensic Science International : Synergy·Thomas W M TamVincent K K Mok
Jan 5, 2002·Pathologie-biologie·V A RamchandaniT K Li
Jul 16, 2002·Nature Neuroscience·Inger Sundstrom-PoromaaSheryl S Smith
Jul 5, 1990·The New England Journal of Medicine
Jan 30, 2004·The British Journal of Nutrition·Klaas R WesterterpArnold D M Kester
Jan 1, 1993·Drug and Alcohol Review·S McLeanM E Jones
Jul 23, 2005·International Journal of Toxicology·Kallirroe ZiavrouTheodore G Vougiouklakis
May 26, 2009·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ruth J BevanLeonard S Levy
Aug 1, 1992·Journal of Toxicology and Environmental Health·M R Montgomery, M J Reasor
Feb 8, 2011·Antioxidants & Redox Signaling·Lorenza González-MariscalMonica Díaz-Coránguez
Aug 10, 1999·Journal of Clinical Psychopharmacology·J S MarkowitzK S Patrick
Jan 1, 1991·British Journal of Clinical Pharmacology·P R JacksonH F Woods
Oct 1, 1992·British Journal of Clinical Pharmacology·Y al-LanqawiI H Stevenson
Jun 1, 1994·British Journal of Clinical Pharmacology·T W GuentertJ Dingemanse
Jun 15, 1999·Drug Metabolism and Drug Interactions·A G Fraser
Dec 20, 2002·Clinical Pharmacokinetics·Ake NorbergJohan L Gabrielsson
Jun 10, 2003·Clinical Pharmacokinetics·Jack Lotsof
Feb 15, 2011·International Journal of Environmental Research and Public Health·Salvador Manzo-Avalos, Alfredo Saavedra-Molina
Jan 1, 1993·Psychopharmacology·A L van SteveninckA F Cohen
Jul 3, 2013·Nutrition Reviews·Elhaseen E ElaminDaisy M Jonkers
Jun 1, 1996·The Journal of Pharmacy and Pharmacology·L I HarrisonP J Wyld
Oct 30, 2012·Clinics in Liver Disease·Arthur I Cederbaum
Jul 27, 2010·The Veterinary Journal·Ibrahim A WasfiB A Agha
Mar 23, 2010·Forensic Science International : Synergy·Alan Wayne Jones
Dec 2, 2008·The American Journal of Emergency Medicine·Anne Lamminpää, Kalle Hoppu
Dec 18, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A ConteM Inghilleri
Aug 28, 2007·Journal of Forensic and Legal Medicine·C Roberts, S P Robinson
May 8, 2007·Emergency Medicine Clinics of North America·Laura K Bechtel, Christopher P Holstege
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·D M Boothe, J Perkins

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