PMID: 6108730Sep 1, 1980Paper

Clinical pharmacokinetics of fazadinium

Anaesthesia
D R BevanR L Smith

Abstract

Fazadinium was administered as an intravenous bolus of 0.5 or 1 mg/kg to nine patients during neurolept-anaesthesia. Continuous recording of neuromuscular activity and serial collection of blood samples for drug assay allowed the relationship between neuromuscular blockade and plasma fazadinium concentration to be studied. Pharmacokinetic analysis demonstrated high plasma clearances (221 and 185 ml/min), and short terminal half-lives, (30 and 50 min), for the two doses of the drug. Mean plasma concentrations at 10 and 50% recovery were 1.42 and 0.88 micrograms/ml respectively, demonstrating that the potency of fazadinium is approximately half that of tubocurarine and one eighth that of pancuronium. In addition, the relationship between plasma concentration and depression of neuromuscular activity during spontaneous recovery from the relaxant is described.

References

Jan 1, 1978·Acta Anaesthesiologica Scandinavica·F Camu, A D'Hollander
Aug 1, 1978·British Journal of Anaesthesia·P DuvaldestinJ M Desmonts
Mar 1, 1976·Anaesthesia·J M Thompson
Jul 1, 1979·Anaesthesia·D R Bevan
Mar 1, 1978·British Journal of Anaesthesia·C A ShanksE J Triggs
Jun 1, 1978·British Journal of Anaesthesia·A A SomogyiE J Triggs
Nov 1, 1978·British Journal of Anaesthesia·C J HullM J Watson
Sep 30, 1976·European Journal of Clinical Pharmacology·A A SomogyiE J Triggs
Oct 2, 1975·The New England Journal of Medicine·D J Greenblatt, J Kock-Weser
Apr 1, 1976·British Journal of Anaesthesia·K McLeodM D Rawlins
Feb 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·U W KerstenS Agoston
Oct 22, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·P G Waser
Nov 1, 1970·British Journal of Anaesthesia·H H AliC Gray

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Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·D R BevanR L Smith

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