Clinical pharmacokinetics of lornoxicam. A short half-life oxicam

Clinical Pharmacokinetics
N M Skjodt, N M Davies

Abstract

Lornoxican (chlorotenoxicam) is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class. Unlike other oxicams, lornoxicam has a relatively short plasma half-life (3 to 5 hours). Lornoxicam is eliminated following biotransformation to 5'-hydroxy-lornoxicam, which does not undergo enterohepatic recirculation. Glucoroconjugated metabolites are excreted in urine and faeces with a half-life of about 11 hours. Lornoxicam and its metabolites bind extensively to plasma albumin. Substantial concentrations of lornoxicam are attained in synovial fluid, the proposed site of action in chronic inflammatory arthropathies. The effects of lornoxicam concentration on its therapeutic and toxicological properties have not yet been extensively reported. Lornoxicam, like other NSAIDs, appears to interact with warfarin, sulphonylureas, digoxin and furosemide.

Citations

Jan 16, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Sudip Kr DasShubhrakanti Sen
Dec 21, 2004·British Journal of Clinical Pharmacology·Yifan ZhangHui Zhou
Jul 16, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Aysegul Mine Tuzuner OnculCahit Ucok
Jul 6, 2013·International Journal of Biological Macromolecules·Yasser ShahzadSyed Nisar Hussain Shah
Jul 25, 2014·Journal of Liposome Research·Ghada Ahmed Abdelbary, Mona Hassan Aburahma
May 30, 2013·Expert Opinion on Pharmacotherapy·Christian Hillstrom, Jan G Jakobsson
Jul 6, 2014·Journal of Pharmaceutical Sciences·Hesham M TawfeekMatthew Roberts
Dec 18, 2007·Journal of Clinical Anesthesia·Kerem InanogluAlper Kararmaz
Mar 24, 2010·Pharmaceutical Development and Technology·Mona Hassan Aburahma, Yassin El-Said Hamza
Nov 19, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·H S Abdel-GhaffarM M Roushdy
Mar 19, 2020·Expert Opinion on Drug Metabolism & Toxicology·Yolanda MacíasJosé A G Agúndez
Aug 25, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·A David Rodrigues
Jul 6, 2011·Basic & Clinical Pharmacology & Toxicology·Chang-Ik ChoiSeok-Yong Lee
Apr 20, 2019·Pain Research and Treatment·Ayman A MetryFady A Abdelmalek
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Jianjun ZhangShuai Qian

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