Clinical pharmacokinetics of tacrolimus after the first oral administration in renal transplant recipients on triple immunosuppressive therapy

Basic & Clinical Pharmacology & Toxicology
Radmila Velickovic-RadovanovicTatjana Cvetkovic

Abstract

Monitoring of tacrolimus blood concentration is of utmost importance in the management of renal transplant recipients because of Narrow Therapeutic Index and highly variable pharmacokinetics. The aim of this study was to detect inter-patient pharmacokinetic variability of tacrolimus and to assess the predictability of individual tacrolimus concentrations at various times of the area under the curve (AUC) seeking to find the best sampling time to predict the exposure of tacrolimus in renal transplant recipients with triple therapy. This oral dose tacrolimus pharmacokinetics study was conducted in 18 Serbian renal transplant recipients on triple immunosuppressive therapy, including basiliximab. The first oral dose of tacrolimus (0.05 mg/kg) was given on day 5 post-transplant; blood concentration was measured by microparticle enzyme immunoassay method. Associations between each sampling time-point of concentrations and AUC(12) were evaluated by Pearson correlation coefficients. Abbreviated sampling equations were derived by multiple, stepwise regression analyses. The variance in the strength of association between predicted AUC (AUC(p)) and AUC(12) was reflected by linear regression coefficients. AUC(12) showed remarkable inter-in...Continue Reading

References

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Citations

Dec 21, 2013·European Journal of Drug Metabolism and Pharmacokinetics·Neven VavicMomir Mikov
May 28, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Gonzalo N Almeida-PauloAntonio J Carcas-Sansuán
Mar 7, 2014·European Journal of Drug Metabolism and Pharmacokinetics·Radmila Velickovic-RadovanovicTatjana Cvetkovic
Feb 7, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nikola Z StefanovićRadmila M Veličković-Radovanović

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