Clinical Pharmacology in HIV Therapy

Clinical Journal of the American Society of Nephrology : CJASN
Mohamed G AttaGregory M Lucas

Abstract

The success of combination antiretroviral therapy in the treatment of HIV-1-positive individuals has shifted clinical attention toward combination antiretroviral drug regimens that optimize tolerability, long-term safety, and durable efficacy. Wherever patients have access to treatment, morbidity and mortality are increasingly driven by non-HIV-associated comorbidities, which may be observed earlier than in age-matched controls and despite the best available combination antiretroviral therapy. Similarly, HIV-1-positive individuals are now diagnosed and treated earlier with anticipated lifelong therapy. The contribution of specific antiretroviral agents to long-term morbidity and mortality is dependent on the pharmacologic characteristics of these agents, and it is increasingly important in this context.

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Mar 4, 2020·Expert Opinion on Drug Metabolism & Toxicology·Ahizechukwu C EkeMark Mirochnick
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Feb 2, 2022·Drug Development Research·Athar HusainJiaur R Gayen

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