Clinical Pharmacology of Frequently Used Intravenous Drugs During Bariatric Surgery in Adolescents

Current Pharmaceutical Design
Janelle D VaughnsJohn N van den Anker

Abstract

Obesity represents one of the most important public health issues according to the World Health Organization. Additionally, in a recent National Health and Nutrition Survey of 2011-2012, approximately 17 % of children and adolescents in the United States were considered obese. The obesity rate is higher within the adolescent age group as compared to preschool children. Childhood obesity is particularly problematic, because the co-morbid disease states which accompany obesity may require frequent pharmacotherapy and/ or surgical intervention. Despite the potential for increased pharmacotherapy among obese patients, there is a paucity of dosing guidelines for this special population. Optimal drug dosing in obese pediatric patients has not been sufficiently explored as the present data available are mostly specific for obese adults. In this review, we present an overview concerning what is currently known about the pharmacokinetics and pharmacogenetics of frequently used drugs including midazolam, fentanyl and its newer derivatives, morphine, ketamine, acetaminophen, dexmedetomidine and enoxaparin in obese adolescents undergoing bariatric surgery. We will also summarize the current dosing recommendations of anesthetic drugs in bar...Continue Reading

Citations

Jul 9, 2017·Clinical Pharmacokinetics·Victoria C ZiesenitzJohannes N van den Anker
Nov 28, 2017·Clinical Pharmacokinetics·Victoria C ZiesenitzJohannes N van den Anker
Apr 27, 2018·Current Opinion in Anaesthesiology·Jerrold Lerman, Karin Becke
Nov 23, 2019·Anaesthesia and Intensive Care·Zahid HussainSyed Tabish R Zaidi
Sep 25, 2018·Journal of Clinical Pharmacology·Barbara Ameer, Michael A Weintraub
May 23, 2020·Obesity·Barbara Ameer, Michael A Weintraub
Mar 4, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Ufuk AtesAydin Yagmurlu
Oct 25, 2020·Hospital Pediatrics·Kathryn E KylerJessica L Bettenhausen
Dec 25, 2017·Journal of Clinical Anesthesia·Vidya ChidambaranMohamed Mahmoud

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